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SMi’s 13th Annual Conference
RNA Therapeutics
9-10 February, 2022 | Conference
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SMi is proud to announce the 13th Annual RNA Therapeutics Conference taking place on 9 - 10 February 2022

RNA therapeutics is a rapidly expanding industry with increasingly growing potential for immunotherapy, personalised medicines, and treatment of genetic, infectious and chronic diseases. This is reflected with the value of the global antisense & RNA therapeutics market expected to reach USD 1.81 billion by 2025, growing at a CAGR of 7.5%. Furthermore, the recent advent of CRISPR, an RNA-guided gene-editing technology, as well as new strides in the delivery of messenger RNA transcribed in vitro, have triggered a major expansion of the RNA-therapeutics field.


The RNA therapeutics industry has grown at an exponential rate in recent years, with an increased spotlight following the industry’s leading role in developing vaccines against COVID-19 in response to the global pandemic. This year’s conference will reflect on how the industry has adapted and played a pivotal role in global health over the past year and will discuss the takeaways for future mRNA therapeutic development. Furthermore, the 2022 agenda will explore innovations in novel and targeted delivery, RNAi innovations and antisense oligonucleotide therapeutics. Global experts from big pharma and leading biotechs will explore the emerging therapeutic applications of RNA with case studies on the treatment of cardiovascular disease, neurological diseases and oncology.

Join us in February 2022, as SMi’s 13th annual RNA Therapeutics Conference brings together industry experts from leading RNA therapeutics companies to gain an expert and holistic view on the latest developments of the industry.
 

 

  • Explore how mRNA vaccines have led the way in the response against COVID-19 and key takeaways for the industry
  • Understand the potential of RNAi and antisense oligonucleotides for the treatment of  cardiovascular and neurological diseases
  • Delve into the latest innovations in novel RNA delivery and target specificity
  • Engage in the growing advances and development of RNA tools for vaccines and anti-infectives

 

Key Job Titles include:

Research & Development Directors/Managers/Scientists
Heads of Clinical Development
Heads of Pre-Clinical Development
Head of RNA Biology
Head of RNA Formulation and Drug Delivery
Head of Pre-clinical R&D
Head of New Modalities
Head of Discovery
Senior Scientists
Chief Scientific Officers
Chief Medical Officers

Global Presence:

Attendees from all over the world attend our events, gain hands on insight from representatives from UK, Europe and USA.

 

Advanced Cell Diagnostics, A Bio-Techne Brand; Aldevron; Aldevron Llc; AMBR Consulting Ltd; AmpTec GmbH; Asahi Kasei Corporation; Astrazeneca; Bachem; BianoGMP; BioNTech RNA Pharmaceuticals; Bio-Techne Ltd; Chiesi Farmaceutici spa; eTheRNA; Ethris GmbH; F.Hoffmann-La Roche AG; Galapagos; GE Healthcare; Genevant Sciences; Genmab A/S; GSK; himed; Imperial College London; Inabata France S.A.S.; Independent; InteRNA Technologies BV; Intertek; Intertek Pharmaceutical Services Manchester; JSC R-PHARM; MHRA; Miescher Pharma GmbH; MiNA Therapeutics; MiNa Therapeutics Ltd; moderna Therapeutics; Nanogenics Ltd; New England Biolabs; NHS Blood and Transplant; NHS Blood and Transplant Authority; Nippon Fine Chemical; Nitto Avecia; Nitto Denko Avecia; Norinnova Technology Transfer AS; Pantherna Therapeutics GmbH; Polyplus-Transfection; Roche Diagnostics Deutschland; Roche Diagnostics Deutschland GmbH; Roche Innovation Center; Royal College of Surgeons in Ireland; Sanofi; Sense Biopharma AS; Symbiosis Pharmaceutical Services Limited; Thermo Fisher Scientific; TranSINE Therapeutics; Univeristy of Gent – Gene Therapy; University Gent; Vaccitech Ltd;
 

Conference programme

8:30 Registration & Coffee

9:00 Chairman's Opening Remarks

Heinrich Haas

Heinrich Haas, Vice President Formulation and Drug Delivery, BioNTech RNA Pharmaceuticals
View Bio

9:10 Reviewing the current environment of R&D and new technologies

Heinrich Haas

Heinrich Haas, Vice President Formulation and Drug Delivery, BioNTech RNA Pharmaceuticals
View Bio

  • How have we seen the industry evolve over the past year?
  • Significant developments in RNA technologies
  • How can the recent acceptance of mRNA vaccines aid further advances in the industry?
  • What are the major hurdles facing the industry and a look to new opportunities in the near future
  • 9:50 Policies relating to medicines and medical devices

    Kirsty Wydenbach

    Kirsty Wydenbach, Deputy Unit Manager/Senior Medical Assessor, MHRA
    View Bio

  • An insight into the MHRA's approach to mRNA vaccines over the past year
  • MHRA updates and guidance on RNA therapeutics
  • Regulatory advice on novel clinical trials
  • 10:30 Morning Coffee

    11:00 mRNA: Removing Bottlenecks in Process Development and Manufacturing

    Rok Sekirnik

    Rok Sekirnik, Head of Process Development, mRNA pDNA, BIA Separations d.o.o
    View Bio

  • Overview of current mRNA based therapeutics
  • Highlight the technical challenges of mRNA production, especially high raw material costs and challenges of downstream purification
  • Share recent success stories demonstrating the power of novel at-line analytics to develop scalable production processes with high yield, purity and stability of mRNA drug substance
  • Discuss future requirements for standardization of the process to create a platform for mRNA manufacturing
  • 11:40 Exploring the chemistry of oligonucleotide therapeutics

    Jimmy Weterings

    Jimmy Weterings, Principal Scientist, AstraZeneca

  • Examining further advances in chemistry that are earlier in the pipeline of oligonucleotide drug candidates
  • Considering the possible effect of delivery systems that may provide extra footholds to improve the potency and specificity of oligonucleotide drugs
  • Focusing on strategies to imbue antisense oligonucleotides with more drug-like properties and their applicability to other nucleic acid therapeutics
  • 12:20 Networking Lunch

    13:20 Exosomes as a multi-modular vehicle for RNA Therapeutics

    David Lowe

    David Lowe, Vice President, Evox Therapeutics Ltd
    View Bio

  • Exosomes are naturally produced by all cells and play multiple roles in intercellular communication
  • Exosomes are an exciting, emerging potential therapy for serious diseases
  • At Evox we are engineering exosomes to deliver a wide variety of different RNA payloads in vivo
  • 14:00 Preclinical to clinical transition of INT-1B3 (LNP-formulated miR-193a-3p mimic): initial lessons learned

    Michel Janicot

    Michel Janicot, Chief Development Officer, InteRNA Technologies BV
    View Bio

  • Moving from preclinical evaluation to first-in-human study
  • Initial PK/PD correlation from preclinical to clinical findings
  • Outlook: potential impact on clinical development acceleration
  • 14:40 Traversing protected tissue barriers for oligonucleotide delivery

    Punit Seth

    Punit Seth, Vice President, Ioinis Pharma
    View Bio

  • Current challenges in delivery of oligonucleotide therapeutics
  • Insights into the use of Transferrin receptor ligands and other approaches to optimise delivery
  • Case Study: Enhancing potency of oligonucleotide therapeutics in muscle tissues
  • A future outlook for enhancing oligonucleotide delivery systems
  • 15:20 Afternoon Tea

    15:50 A new era of programmable therapeutics to upregulate genes

    Alfica Sehgal

    Alfica Sehgal, VP Head of Discovery, CAMP4 Therapeutics
    View Bio

  • RNAs role in genome organization and gene expression and insights into the current use of regulatory RNAs in industry
  • Targeting regRNA to increase gene expression and the use of RNA actuators to increase regRNA activity and restore levels of mRNA expression
  • Understanding the technology behind programmable therapeutics for RNA targets in conjunction with RNA actuator technology
  • Looking forward to pipelines in neurological and hepatocyte therapy
  • 16:30 Small Activating RNAs: From Concept to Phase 2 Clinical Trial

    Nagy Habib

    Nagy Habib, Head of HBP Surgery, Co-Founder, Imperial College London and MiNA Therapeutics
    View Bio

  • Small activating RNAs (saRNA) are double stranded 21 nucleotide RNA that either target promoters or enhance genes leading to mRNA upregulation
  • saRNAs can be delivered with liposomes into the systemic circulation or subcutaneously by conjugation with aptamers or GalNAC
  • MTL-CEBPA is an investigative drug that resulted from the conjugation of saRNA CEBPA with NOV 340 lipsomes that targets tumour associated macrophages in order to alter favourably the tumour microenvironment
  • MTL-CEBPA has been administered safely in over 100 patients with advanced cancer and improved clinical outcome in a sub-set of patients when co-administered with TKI or check point inhibitor
  • 17:10 Therapeutic development using chemically modified asymmetric siRNAs

    Dong Ki Lee

    Dong Ki Lee, CEO, OilX Pharmaceuticals
    View Bio

  • RNA interference (RNAi)-based gene silencing has become the 3rd therapeutic development platform with multiple FDA-approved RNAi drugs on market
  • OliX’s asymmetric siRNA (asiRNA) triggers efficient target gene silencing with reduced non-specific effects 
  • OliX Pharmaceuticlas has developed lipid-conjugated cp-asiRNA for local administration therapeutics, and GalNAc-asiRNA for liver targeting therapeutics
  • I will describe OliX Pharmaceuticals’ pre-clinical and clinical developments against various disease indications including (1) local administration therapeutics such as skin scar, androgenic alopecia, and age-related macular degeneration, (2) liver therapeutics such as hepatitis B virus (HBV), non-alcoholic steatohepatitis (NASH), and diabetes.
  • 17:50 Chairman’s Closing Remarks and Close of Day One

    8:30 Registration & Coffee

    9:00 Chairman's Opening Remarks

    Heinrich Haas

    Heinrich Haas, Vice President Formulation and Drug Delivery, BioNTech RNA Pharmaceuticals
    View Bio

    9:10 Programmable mRNA-targeting gene therapy to correct genetic diseases

    Rea Lardelli

    Rea Lardelli, Senior Scientist, Locanabio
    View Bio

  • An introduction to CORRECTX: Locanabio’s programmable RNA-binding protein platform 
  • Application of splicing modulation modality in ocular disease 
  • Emerging approaches for durable splice modulating therapeutics
  • 9:50 Validation of therapeutic mode of action for heart failure program

    Thomas Thum

    Thomas Thum, Founder and Chief Scientific Officer, Cardior Pharmaceuticals
    View Bio

  • The landscape of microRNA for targeted therapy and miR-132’s key role in cardiovascular diseases
  • Investigating the molecular mechanisms of microRNAs in modulating cardiomyocyte contractility
  • Understanding the study findings and the approach of blocking miR-132 to halt the process of cardiac disease
  • What’s next? Moving on to phase 2 studies
  • 10:30 Morning Coffee

    11:00 Reimagining heart treatments via precision therapeutics

    Samir Ounzain

    Samir Ounzain, CEO, HAYA Therapeutics
    View Bio

  • Delving into HAYA’s innovative tissue- and cell-selective genomic medicines
  • How is the discovery engine using long coding RNAs to treat serious health conditions
  • Identifying novel targets and drug candidates with potential for greater efficacy and safety
  • Targeting Wisper and preclinical results showing the potential to reverse fibrotic processes and underlying heart failure
  • 11:40 Engineering the Future of mRNA Therapies

    Volker Germaschewski

    Volker Germaschewski, Senior Vice President of Research & Development, eTheRNA Immunotherapies NV
    View Bio

  • Challenges and limitations of current mRNA technology
  • Applications for a developing technology and the tools to do it
  • The importance of process and supply
  • 12:20 Networking Lunch

    13:20 Systematic identification of novel microRNA targets for epilepsy treatment

    Cristina R. Reschke

    Cristina R. Reschke, Lecturer, Royal College of Surgeons in Ireland
    View Bio

  • Temporal Lobe Epilepsy (TLE) and the therapeutic challenge – why do we need to address that?
  • MiRNAs as targets for epilepsy treatment - what do we know so far & what are we missing?
  • EpimiRNA project: Systematic identification of novel miRNA targets for seizure suppression in TLE
  • 14:00 MicroRNA-335 modulates voltage-gated sodium channels and may be a new therapeutic target in epilepsy

    Gareth Morris

    Gareth Morris, ERUK Emerging Leader Research Fellow, University College London
    View Bio

  • MicroRNA-335 is dysregulated in drug-resistant epilepsies
  • MicroRNA-335 represses multiple voltage-gated sodium channels in the brain
  • Manipulation of microRNA-335 can alter brain excitability and may be beneficial in epilepsy
  • 14:40 RNA Therapeutics in Oncology: Advances and Challenges

    Gayatri Arun

    Gayatri Arun, Vice President of Biology, Envisagenics Inc

  • With the support of Envisagenics’ proprietary machine learning modules, high performance computing, and splicing analytics, Envisagenics identified a novel target and designed and validated RNA therapeutic compound in 8 months
  • Focusing on antisense oligonucleotides as a viable therapeutic modality in oncology and other applicable therapeutic areas
  • Overcoming limitations to computational outputs and executing necessary validation experiments for in-silico identified targets
  • 15:20 Afternoon Tea

    15:50 The Evolution and Expansion of RNA-based Therapeutics

  • Defining applicable therapeutic areas for RNA-based therapeutics and the current promising and accepted disease areas
  • Investor outlook on RNA therapeutics and their appetite for RNA-based companies
  • Spectrum of RNA therapeutics (miRNA, ASO, mRNA, siRNA, etc.)
  • Roles of small molecules in RNA therapeutics
  • Modality comparison (small molecule vs. antisense; delivery vs. generalizable drugs) and pros and cons of RNA-based therapeutics
  • Martin Akerman

    Martin Akerman, CTO & Co-Founder, Envisagenics
    View Bio

    Michel Janicot

    Michel Janicot, Chief Development Officer, InteRNA Technologies BV
    View Bio

    Thomas Thum

    Thomas Thum, Founder and Chief Scientific Officer, Cardior Pharmaceuticals
    View Bio

    Nagy Habib

    Nagy Habib, Head of HBP Surgery, Co-Founder, Imperial College London and MiNA Therapeutics
    View Bio

    Tamar Grossman

    Tamar Grossman, Global Head of RNA and Targeted Therapeutics, Janssen Pharmaceutical Companies of Johnson & Johnson
    View Bio

    16:30 Targeting the Noncoding Genome for the Development of RNA Therapies

    Samir Ounzain

    Samir Ounzain, CEO, HAYA Therapeutics
    View Bio

  • New concepts for the identification of tissue, cell-type, and disease specific regulatory ncRNA targets
  • RNA-targeting modalities and approaches to tame the genome's dark side
  • Translational potential of next-generation lncRNA targets
  • 17:10 The Successes and Failures of RNA-based Therapeutics and Future Outlook

  • Considerations of important characteristics and biology targeting RNA molecules directly.
  • Pipeline and process overview of target selection criteria and ensuring therapeutic viability and specificity.
  • Transforming antisense into a drug and taking sequence into consideration to understand potential off-target effects.
  • Drug delivery considerations, chemistry considerations, and IP strategy
  • Future outlook of RNA-based therapeutics (impact of COVID in the RNA field) and innovative companies in the last 10 years in this respective field
  • Martin Akerman

    Martin Akerman, CTO & Co-Founder, Envisagenics
    View Bio

    Samir Ounzain

    Samir Ounzain, CEO, HAYA Therapeutics
    View Bio

    Sudhir Agrawal

    Sudhir Agrawal, Founder and President, ARNAY Sciences

    Eric Lim

    Eric Lim, Associate Director, Bioinformatics, Stoke Therapeutics, Inc

    17:50 Chairman’s Closing Remarks and Close of Day Two

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    FEATURED SPEAKERS

    Alfica Sehgal

    Alfica Sehgal

    VP Head of Discovery, CAMP4 Therapeutics
    Cristina R. Reschke

    Cristina R. Reschke

    Lecturer, Royal College of Surgeons in Ireland
    David Lowe

    David Lowe

    Vice President, Evox Therapeutics Ltd
    Dong Ki Lee

    Dong Ki Lee

    CEO, OilX Pharmaceuticals
    Gareth Morris

    Gareth Morris

    ERUK Emerging Leader Research Fellow, University College London
    Heinrich Haas

    Heinrich Haas

    Vice President Formulation and Drug Delivery, BioNTech RNA Pharmaceuticals
    Kirsty Wydenbach

    Kirsty Wydenbach

    Deputy Unit Manager/Senior Medical Assessor, MHRA
    Martin Akerman

    Martin Akerman

    CTO & Co-Founder, Envisagenics
    Michel Janicot

    Michel Janicot

    Chief Development Officer, InteRNA Technologies BV
    Nagy Habib

    Nagy Habib

    Head of HBP Surgery, Co-Founder, Imperial College London and MiNA Therapeutics
    Punit Seth

    Punit Seth

    Vice President, Ioinis Pharma
    Rea Lardelli

    Rea Lardelli

    Senior Scientist, Locanabio
    Samir Ounzain

    Samir Ounzain

    CEO, HAYA Therapeutics
    Thomas Thum

    Thomas Thum

    Founder and Chief Scientific Officer, Cardior Pharmaceuticals
    Volker Germaschewski

    Volker Germaschewski

    Senior Vice President of Research & Development, eTheRNA Immunotherapies NV

    Alfica Sehgal

    VP Head of Discovery, CAMP4 Therapeutics
    Alfica Sehgal

    Alfica is VP at CAMP4, heading the discovery, preclinical and translational research. Before CAMP4, she was at Alnylam Pharmaceuticals, where she held multiple roles. Alfica was the program leader for Alpha-1 antitrypsin deficiency related liver disease, driving the program from bench to Phase 1, as well as the program research lead for the fitusiran program for the treatment of haemophilia and rare bleeding disorders. She was also a member of the platform team and next wave team responsible for generating and triaging new pipeline programs.
    Alfica received her post-doctoral training at Johns Hopkins University and Yale University, studying lipid uptake, cholesterol and oxygen homeostasis in parasites, mammalian cells and mice. She received her doctoral degree from the Tata Institute of Fundamental Research (India) in naturally acquired immunity against malarial parasites. She has published more than 30 articles and book chapters in peer-reviewed journals and has authored 17 patents and PCT applications.
     

    Arun Kumar

    Preclinical Vaccine Development Lead, Coalition for Epidemic Preparedness Innovations (CEPI)
    Arun Kumar

    Cristina R. Reschke

    Lecturer, Royal College of Surgeons in Ireland
    Cristina R. Reschke

    Cristina Reschke is Lecturer in the School of Pharmacy and Biomolecular Sciences at the RCSI University of Medicine and Health Sciences and a Funded Investigator of the FutureNeuro Research Centre. She trained as a Pharmacist with a M.Sc. (2010) and Ph.D. (2013) in Pharmacology with research focusing on the effects of neuroinflammation in epilepsy (UFSM, Brazil). Cristina then joined Prof. David Henshall’s group in Ireland to advance discoveries on the role of microRNAs in experimental and human epilepsy. Her work has been internationally awarded, including prestigious young neuroscientists Awards endowed by the International League Against Epilepsy (ILAE) and the American Epilepsy Society (AES). In 2020, Cristina was the recipient of the inaugural CURE Epilepsy Cameron Boyce Foundation Taking Flight Award to establish her own laboratory and investigate the impact of the circadian rhythm dysregulation in epilepsy. Cristina actively serves the Young Epilepsy Section (YES) of the ILAE supporting the training of a new generation of epilepsy experts poised to discover and deliver state-of-the-art care to people with epilepsy well into the future.


     

    David Lowe

    Vice President, Evox Therapeutics Ltd
    David Lowe

    David’s extensive experience at Astra Zeneca includes having accountability for the isolation and optimisation of antibodies, proteins, and peptides for therapeutic development. He and his team delivered lead molecules for the Respiratory, Inflammatory, and Autoimmunity antibody projects. David was the Global Head of In Vivo Expressed Biologics at AZ focusing on exploring and advancing new technologies such as AAV, DNA, mRNA and exosome delivery of biologics. David spent nearly 10 years at Cambridge Antibody Technology, prior to it being acquired by Astra Zeneca, where he led antibody engineering to develop novel antibody-based drugs. David has over 40 scientific publications, and is an inventor on numerous patents. David earned his Ph.D. from the University of Cambridge.d Process Development at AZ and holds an MSc in Biochemistry and Biotechnology.

    Derek O Hagan

    Senior Advisor, GSK
    Derek O Hagan

    Dong Ki Lee

    CEO, OilX Pharmaceuticals
    Dong Ki Lee

    Professor of Chemistry, Sungkyunkwan University, Korea
    Founder and CEO, OliX Pharmaceuticals, Korea

    Prof. Dong-ki Lee received B. S. in Chemistry from Korea Advanced Institute of Science and Technology (KAIST) in 1993, and Ph. D. in Biochemistry from Cornell University in 1999. After post-doctoral training in Pohang University of Science and Technology (POSTECH), Toolgen Inc., and KAIST, he joined POSTECH as an assistant professor in 2004. In 2008, He moved to Sungkyunkwan University and is a full professor of Chemistry since 2012. In 2008, Prof. Lee was selected as the principal investigator of the Global Research Laboratory program, funded by Korean government, to develop novel RNAi medicine. He is currently serving as the Asian editor of “Nucleic Acid Therapeutics” and a editorial board member of "Molecular Therapy: Nucleic Acids". His work on novel siRNA structures, nucleic acid aptamers, and eukaryotic gene regulation has been published as over 80 papers including prestigious journals such as Nature, Cell, PNAS, and Molecular Therapy. In 2010, he founded OliX Pharmaceuticals, a publicly traded RNAi therapeutics company, and serves as Chief Executive Officer.
     

    Eric Lim

    Associate Director, Bioinformatics, Stoke Therapeutics, Inc
    Eric Lim

    Gal Cafri

    Immunotherapy and Genetic Engineering Group leader, Sheba Medical Center
    Gal Cafri

    Gareth Morris

    ERUK Emerging Leader Research Fellow, University College London
    Gareth Morris

    Gareth completed his PhD at the University of Birmingham in 2014, studying high frequency brain oscillations in epilepsy. He then worked as a postdoc at University College London’s Institute of Neurology, as part of the EU ‘EpimiRNA’ consortium. Since then he has made numerous key contributions to the field of microRNA and epilepsy, winning several national and international research prizes. In 2021 Gareth completed a Marie Sklodowska-Curie Actions Individual Fellowship at the Royal College of Surgeons in Ireland, and has recently started his own research group at University College London with funding from Epilepsy Research UK.

    Gayatri Arun

    Vice President of Biology, Envisagenics Inc
    Gayatri Arun

    Heinrich Haas

    Vice President Formulation and Drug Delivery, BioNTech RNA Pharmaceuticals
    Heinrich Haas

    Heinrich has more than 20 years of experience in academic research and industrial pharmaceutical development. His focus is on development for advanced drug delivery systems. After he received his Ph.D. in physical chemistry, he researched lipid membranes and organized biomolecular systems. He was responsible for projects in different biopharmaceutical companies for research and development of diagnostic and therapeutic carrier systems. Joining BioNTech in 2010, he helped build the formulation development and analytics unit, which develops formulations for delivery of RNA and small molecules.

    Jimmy Weterings

    Principal Scientist, AstraZeneca
    Jimmy Weterings

    Kirsty Wydenbach

    Deputy Unit Manager/Senior Medical Assessor, MHRA
    Kirsty Wydenbach

    Dr Kirsty Wydenbach is a Senior Medical Assessor and the Deputy Unit Manager in the Clinical Trials Unit, having joined the MHRA in 2009. She has been involved in the UK regulation of clinical trials across all therapy areas and all phases of development, including ATMPs and many first-in-man studies. She has also been involved in European discussions aiming to establish an EU harmonised approach to clinical trials, particularly for Developmental Safety Update Reports (DSURs) and Reference Safety Information (RSI). She was also an EMA expert for the update of the First-in-Human guideline. Other recent work has included collaboration with external industry groups and regulators regarding adaptive and novel trial designs: she is leading on this aspect for the MHRA in order to implement that aspect of the Life Sciences Industrial Strategy, and was a contributor to the EU CTFG “Recommendation Paper on the Initiation and Conduct of Complex Clinical Trials”. More recently Kirsty has overseen the clinical trial work for COVID-19 and provided regulatory expertise on vaccines both within MHRA but also as part of the government Vaccine Taskforce.

     

    Kyeongmi Kim

    Principal Scientist, mCureX Therapeutics
    Kyeongmi Kim

    Martin Akerman

    CTO & Co-Founder, Envisagenics
    Martin Akerman

    Martin Akerman is the Co-founder and CTO of Envisagenics. He is the inventor of the SpliceCore® platform, Envisagenics’ flagship AI technology for the discovery of splicing-based therapeutic targets. Martin trained as a post doctorate fellow with Dr. Adrian Krainer from Cold Spring Harbor Laboratory. He received his PhD in Bioinformatics from Technion, Israel Institute of Technology. As a first-time entrepreneur, Martin represented Envisagenics in winning the J&J AI for Drug Discovery QuickFire challenge in 2017 and Microsoft’s Innovate.AI challenge in 2018. His goal is to combine cutting-edge computation with RNA domain expertise to develop innovative drugs for cancer and genetic diseases.

    Michel Janicot

    Chief Development Officer, InteRNA Technologies BV
    Michel Janicot

    Michel holds a Ph.D. degree in Biochemistry (Paris VII. France) and was Postdoctoral Fellow in the Dept. of Biological Chemistry (M. Daniel Lane) at The Johns Hopkins University (Baltimore, MD. USA). He has over 25-years hands-on experience in Oncology preclinical and early clinical pharmaceutical drug development in increasing leadership and managerial roles at Rhone-Poulenc Rorer (Sanofi) and subsequently, at Janssen (Johnson & Johnson). Since 2012, Michel is the founder and Managing Director of JMi ONConsulting, a Brussels-based consulting firm specialized in providing services and guidances for research and development programs in Oncology, Inflammation, Immunology, Vaccines, COPD, MS, Diabetes, Fibrosis and Ophthalmology.

    Nagy Habib

    Head of HBP Surgery, Co-Founder, Imperial College London and MiNA Therapeutics
    Nagy Habib

    Nagy Habib is a leading translational researcher on liver cancer and its treatment. He pioneered the first clinical trial in the use of adenovirus and plasmid for the treatment of liver cancer, as well as the use of plasmid gene therapy in hydrodynamic gene delivery. He is the first person in the West to publish a clinical trial on the use of adult bone marrow derived stem cells for the treatment of patients with liver insufficiency.

    He has published on the evolution of molecular biology of tumours from oncogene, tumour suppressor gene, epigenetic modification, gene therapy, stem cell therapy, RNA (Ribonucleic acid) and saRNA (small activating RNA) and RNA aptamers.

    He is the inventor of, and was co-author of the first publication about the use for radiofrequency in devices used in liver surgery (Habib™ 4X), as well as interventional endoscopy (Habib™ EndoHPB – HPB: Hepatopancreatobiliary) and interventional radiology (Habib™ Percutaneous HPB, Habib™ VesCoag, Habib™ VesOpen).

    Nagy is currently Lead Clinician and Head of the Department of HPB Surgery at Imperial College London. In June 2007 he was also appointed Pro Rector for Commercial Affairs at the university. He holds a gold award from the Advisory Committee for Clinical Excellence, which is given in recognition of exceptional contributions from NHS consultants, and he was named as one of Britain’s top surgeons in December 2011 by the Saturday Times Magazine. In December 2012, he was awarded the TAKREEM AWARD for Science and Technology for scientific work in liver cancer and the technological development of the Habib 4X surgical device. In 2015, Nagy was awarded a Foreign Membership of the prestigious French Académie Nationale de Chirurgie.
     

    Punit Seth

    Vice President, Ioinis Pharma
    Punit Seth

    Dr. Punit P. Seth heads medicinal chemistry and targeted delivery at Ionis Pharmaceuticals. Dr. Seth is co-inventor of Ionis’ Gen 2.5 platform which employs high affinity nucleoside modifications to enhance the affinity, stability and potency of ASOs in the liver and in extra-hepatic tissues. He is also the co-inventor of Ionis’ LICA (ligand conjugated antisense oligonucleotides) platform which enhances ASO potency by targeted delivery to cells and tissues of interest. He has extensive experience with using medicinal chemistry strategies to modulate the activity, pharmacokinetic and toxicological properties of oligonucleotide drugs. Dr. Seth is listed as co-author/co-inventor on over 200 peer-reviewed publications, issued patents and patent applications. He has a Ph.D in organic chemistry from The Ohio State University.

     

    Rea Lardelli

    Senior Scientist, Locanabio
    Rea Lardelli

    Rea Lardelli, PhD, joined Locanabio in February 2020 and is Senior Scientist in RNA biology. She leads the splicing modulation team and serves as the functional leader for Locanabio’s ocular program. Before coming to Locanabio, Rea was an NRSA and IRACDA postdoctoral fellow at University of California, San Diego and the Ludwig Institute for Cancer Research in Melbourne, Australia where her studies focused on molecular mechanisms of post-transcriptional regulation. Rea received her doctoral degree in Biochemistry from The University of Texas, where she studied RNA-protein complexes, and her BS from Cal Poly, San Luis Obispo.

    Rok Sekirnik

    Head of Process Development, mRNA pDNA, BIA Separations d.o.o
    Rok Sekirnik

    Rok Sekirnik graduated with a degree in chemistry from the University of Oxford, where he also completed his PhD. His team at BIA Separations, now a Sartorius company, is focused on developing high-yielding, cost-effective purification approaches for pDNA and mRNA production.

    Samir Ounzain

    CEO, HAYA Therapeutics
    Samir Ounzain

    Samir Ounzain is a molecular biologist with over 15 years of experience exploring the dark matter of the genome and its roles in development and disease. Prior to founding HAYA Therapeutics, Samir was a Project Leader and Research Fellow at the Lausanne University Hospital (CHUV), where his research efforts directly led to the discovery of hundreds of novel heart-enriched lncRNAs, most notably the lncRNAs CARMEN, Meteor and Wisper.

    Steve Pascolo

    Founder and CEO, Miescher Pharma GmbH
    Steve Pascolo

    Sudhir Agrawal

    Founder and President, ARNAY Sciences
    Sudhir Agrawal

    Sun Woo Hong

    CEO, mCureX Therapeutics
    Sun Woo Hong

    Tamar Grossman

    Global Head of RNA and Targeted Therapeutics, Janssen Pharmaceutical Companies of Johnson & Johnson
    Tamar Grossman

    Dr. Tamar R. Grossman is the Global Head of RNA and Targeted Therapeutics at Janssen Pharmaceutical Companies of Johnson and Johnson. Tamar is responsible for the delivery of RNA based development candidates across all therapeutic areas. Previously, she was a Senior Director and Head of Rare Diseases at Arcturus Therapeutics where she developed RNA therapeutics across different RNA technologies. Prior to Arcturus, Tamar was the Director of Translational Medicine at Ionis Pharmaceuticals where she led various antisense oligonucleotide research programs to clinical development. She received her PhD in Biochemistry from Tel-Aviv University and complete postdoctoral research training at the UCSD.

    Thomas Thum

    Founder and Chief Scientific Officer, Cardior Pharmaceuticals
    Thomas Thum

    Thomas Thum studied medicine in Hannover, with state examination in 2001 and board examination for internal medicine/cardiology in 2009/2010. He received his PhD at the Imperial College, London (2008). He is a full professor and director of the Institute of Molecular and Translational Therapeutic Strategies at the Hannover Medical School (MHH), Visiting Professor at the Imperial College, director of MHH’s Center for Translational Regenerative Medicine and director of the Fraunhofer Institute for Toxicology and Experimental Medicine. He (co-) authored > 400 publications and >40 patents and is a distinguished reviewer, board member, and founder.

     

    Volker Germaschewski

    Senior Vice President of Research & Development, eTheRNA Immunotherapies NV
    Volker Germaschewski

    Volker Germaschewski, PhD joins from Kymab Ltd. (Cambridge, UK) where, over 10 years, he was initially Senior Director Discovery and subsequently Vice President of Haematology. Prior to that he held several positions in Biopharm R&D at GlaxoSmithKline.

    Wigard Kloosterman

    Chief Scientific Officer, Frame Therapeutics
    Wigard Kloosterman

    Sponsors

    Supporters

    Focus Days

    Vaccines in the RNA Industry
    Focus Day

    Vaccines in the RNA Industry

    Copthorne Tara Hotel
    8th February 2022
    London, United Kingdom

    VENUE

    Copthorne Tara Hotel

    Scarsdale Place, Kensington, London, United Kingdom

    The Copthorne Tara Hotel London Kensington is an elegant contemporary four-star hotel in prestigious Kensington, located just a two minutes walk from High Street Kensington underground station, making exploring easy. The hotel offers well-appointed and comfortable guest rooms combining Standard, Superior and Club accommodation. Club rooms offer iconic views over the city and include Club Lounge access for complimentary breakfast and refreshments. Guests can sample the authentic Singaporean, Malaysian and Chinese cuisine at Bugis Street, traditional pub fare at the Brasserie Restaurant & Bar or relax with a delicious drink at West8 Cocktail Lounge & Bar.

    The Copthorne Tara Hotel boasts 745 square meters of flexible meeting space, consisting of the Shannon Suite and the Liffey Suite, ideal for hosting conferences, weddings and social events. Facilities include access to the business centre 24 hours a day, fully equipped fitness room, gift shop, theatre desk and Bureau de Change. With ample onsite parking outside the London congestion charge zone and excellent transport links via Heathrow Airport, the hotel is the perfect location for business or leisure stays. The hotel is within close proximity to the shops of High Street Kensington, Knightsbridge and Westfield London, Olympia Conference Centre, Royal Albert Hall, Kensington Palace and Hyde Park.

     

    A number of our clients have been approached by third party organisations offering to book hotel rooms. We would advise that you do not book through them as they are not representing the SMi Group. SMi Group books all hotel rooms directly. If you are approached by a third party organisation then please contact us before making any bookings. If you have already booked a hotel room using a third party organisation, we would highly recommend contacting the hotel you were booked into to ensure a booking has been made for you. We would also advise you to please check the terms and conditions of the booking carefully.
    HOTEL BOOKING FORM

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    RNA Therapeutics 2022 Brochure

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    Past Attendees

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    Sponsors


    BIA Separations

    Sponsors
    http://www.biaseparations.com

    BIA Separations, now a Sartorius company, develops and manufactures market-leading CIM® monolithic chromatographic columns for purification and analysis of large biomolecules, such as viruses, plasmids and mRNA, which are applied in cell and gene therapies. BIA's technology for manufacturing-scale purification is already used in production of the first commercialized advanced therapeutics; BIA also has a keen presence with novel drug candidates in the clinical pipeline. Expecting continued strong double-digit sales growth over the next few years, BIA earned sales revenue approx. 25 million Euros in 2020, contributing to Sartorius Bioprocess Solutions, part of the Sartorius Group.



    eTheRNA

    Sponsors
    http://www.etherna.be

    eTheRNA immunotherapies is a private clinical-stage company driving mRNA technology and therapeutic product development to deliver an innovative generation of RNA chemistries, RNA process technologies and a new and advanced generation of therapeutic and vaccine products. eTheRNA uses its established R&D foundations and in-house GMP manufacturing facilities and builds on its proprietary mRNA, mRNA adjuvant and mRNA formulation platforms to progress technology innovation and product development.

    eTheRNA was established in January 2013 as a spin-off company from the ‘Vrije Universiteit Brussel’ (VUB), following the development of its TriMix mRNA technology.


    Media Partners


    Gate2Biotech

    Supporters
    http://www.gate2biotech.com

    Gate2Biotech is a portal that unites biotechnological community in Central Europe. It covers all the news in the field of biotechnology. Thanks to the the portal the companies engaged in the field can easily search for research institutions and other partners to solve technical problems they are facing and here they can also present their services offer to potential partners from the Czech Republic and abroad. Gate2Biotech portal serves as a bridge connecting scientific and commercial sector. It incorporates offices and support organizations dedicated to promoting transfer of innovative technologies into a unified communication platform of Czech and international biotechnologies. As a mediator of information it draws attention to biotechnologies and support of their application and transfer into practice. It also functions as a tool for encouraging non-professionals (especially scientists and students) towards innovative business or applied research.


    IPI

    Supporters
    http://international-pharma.com/

    International Pharmaceutical Industry is a peer-reviewed journal. We are committed to editorial integrity. Supported by an elite group of reviewers and industry experts, IPI brings you contemporary and authoritative articles which will guide the industry in the best practice in regulatory issues, market analysis, drug discovery, development, delivery methods, clinical research, laboratories, analytical testing, custom and contract manufacturing, primary and secondary packaging, logistics and supply chain management.


    pharmaphorum

    Supporters
    http://www.pharmaphorum.com

    pharmaphorum drives innovation within the pharmaceutical industry, by bringing healthcare together through a suite of media services that help produce and disseminate thought leadership, combined with an online platform for communicating messages to a global audience.Visit www.pharmaphorum.com


    Drug Development Technology

    Supporters
    http://www.drugdevelopment-technology.com

    Drugdevelopment-technology.com covers every aspect of the drug development and research process, from conception to pre-FDA approval. Our global network of journalists updates the site with the latest and most significant industry developments. This coverage allows us to provide everyone - from senior management through to research and QA staff – with in-depth reviews of the latest projects, advance notice of new product releases and analysis of the latest procedural and legislative developments.


    Labiotech.eu

    Supporters
    https://goo.gl/DRE2Gp

    Labiotech.eu is the leading digital media covering the European Biotech industry. Over 100,000 monthly visitors use it to keep an eye on the business and innovations in biotechnology. Hope you'll enjoy reading our stories!


    Genomeweb L L C

    Supporters
    http://www.genomeweb.com

    GenomeWeb LLC is an independent, privately-held online and print publisher based in New York. Since 1997, GenomeWeb has served the global community of scientists, technology professionals, and executives who use and develop the latest advanced tools in molecular biology research and molecular diagnostics.

    GenomeWeb’s editorial mission is to serve readers with exclusive, in-depth coverage of the technology, institutions, and scientists that make up the worldwide research enterprise of molecular biology. We operate the largest online news organization focused on advanced research tools in genomics, proteomics, and bioinformatics.

    GenomeWeb readers can be found in major biopharmaceutical companies, top research universities, biomedical institutes, and government laboratories.


    Mednous

    Supporters
    http://www.MedNous.com

    MedNous is a print publication and website about medical innovation in Europe. It carries exclusive interviews with companies that are at the forefront of medical technology, as well as contributor articles from prominent practitioners. Our mission is to identify significant advances in medicine and to explain how this innovation is being commercialised. In doing so, we talk to venture capitalists about what products and platforms they are supporting. We report on how regulators cope with the accelerating pace of innovation. And we regularly cover the latest developments in the discovery and development of new medical concepts in the area of antibodies, vaccines, small molecules, regenerative medicine and nanomedicines. MedNous combines the English word for medicine with the Greek word for intellect. And those with nous are readers of our publication. Visit our website: www.mednous.com


    Pharmalicensing

    Supporters
    http://www.pharmalicensing.com

    Pharmalicensing (www.pharmalicensing.com) is the premier biopharmaceutical Open Innovation resource designed for professionals involved with partnering, licensing and business development worldwide. Actively supporting all forms of partnering and in- and out-licensing activities, Pharmalicensing utilizes the unique online Showcase Profiling & Discover services, as well as its renowned Partnering Search service leveraging its global network of industry experts, to enable companies to identify and engage with appropriate partners around the world. Pharmalicensing is actively utilized by many tens of thousands of industry professionals each month. Pharmalicensing is a division of Cognis Group, Inc.


    Drug Discovery Today

    Supporters
    http://www.drugdiscoverytoday.com/

    Drug Discovery Today covers the whole of the preclinical drug discovery process. The reviews are cutting edge, written by experts in their respective fields and cover all aspects of drug discovery from genomic and proteomic approaches, computational drug design, medicinal chemistry and the translation of these sciences to therapies.


    Farmavita

    Supporters
    https://farmavitar.com

    FarmavitaR+ is the professional network of experts and service providers. Network is gathering local consultants from 90 countries in Europe, Asia, North America, Latin America, Australia and Africa. Management of international, multi-centre projects is our core competence. FarmavitaR+ is providing solutions related to pharmaceutical, medical device, food supplement and cosmetic products. Scope of services is related to solutions for product development, quality assurance, clinical trials, product registration, portfolio analysis, lifecycle management, vigilance/risk management, pricing/reimbursing, market access and promotional compliance. FarmavitaR+ is brand name of Farmavita Regulanet Ltd. Visit https://farmavitar.com for more information. Outsource anything you can think of!


    Pharma Journalist

    Supporters
    http://www.pharmajournalist.com

    Pharma Journalist is a product of Kellen Media. Pharma Journalist is one of the leading website covering the need of global Pharmaceutical Industry. Articles like latest news, trends, analysis, market report, press releases, whitepapers, case studies, etc. published on pharmajournalist.com helps Industry professionals and decision makers to stay on the top of this fast-paced industry. Pharma Journalist aims of providing fast and informative articles to its readers and subscribers.


    American Pharmaceutical Review

    Supporters
    http://www.americanpharmaceuticalreview.com

    Start receiving your free copy today. American Pharmaceutical Review is a review of the drug pipeline from the late discovery phase through manufacturing. American Pharmaceutical Review prides itself on having the most relevant, unbiased and informative editorial in the industry. You will find that all of our editorial is highly technical and written by government agencies, consultants, academics, and large pharmaceuticals companies. American Pharmaceutical Review covers several key topics that are important to drug production:Separations and purification, Drug Delivery, Biopharmaceutical Processing, Biopharmaceutical Development, Formulation development, Manufacturing, Microbiology, Instrumentation, Spectroscopy


    Pharmaceutical Technology

    Supporters
    http://www.pharmaceutical-technology.com

    Pharmaceutical-technology.com is the only website focusing specifically on issues relevant to pharmaceutical professionals working with technology, be it development, engineering, IT or production. Pharmaceutical-technology.com brings you the latest in industry projects and updates, along with the news, views and trends that leading professionals – from senior executives to manufacturing managers and heads of procurement – require to stay on top of their field.


    ASD MEDIA

    Supporters
    http://www.asd-network.com

    Professionals in the Aerospace & Defence market use the ASD Media internet platforms to:
    • Be informed on the latest market developments; www.asd-network.com
    • Find the latest business news; www.asd-network.com
    • Find the upcoming events; www.asd-network.com
    • Find companies and organizations; www.asdsource.com
    • Distribute news globally. www.asdwire.com
    The ASD Media platforms are well known and used intensively, your company is able to benefit from these large numbers of users. Be informed with ASD-Network; Create exposure for your company with ASDSource, distribute your news with ASDWire or advertise with us, build your brand and increase traffic to your company’s website.

    For more detailed information please contact with: ASD MEDIA
    Stefan.koopman@asdmedia.nl


    On Drug Delivery

    Supporters
    http://www.ondrugdelivery.com/subscribe

    ONdrugDelivery provides 30,000 readers throughout global pharma/biopharma, with the latest, most pertinent industry information and intelligence about the drug delivery-related ideas, technologies, services and products the sector is developing. Established in 2004, and trusted throughout the industry for its high quality contributions from leading drug delivery experts, ONdrugDelivery is a must for pharma / biotech industry professionals who need to know what’s going on in drug delivery. Subscribe online today to the print or free digital edition: www.ondrugdelivery.com/subscribe.


    Pharmacircle

    Supporters
    http://www.pharmacircle.com

    PharmaCircle is an innovative knowledge management company serving the current and future global leaders in the Pharmaceutical and Biotechnology related industries. PharmaCircle is a one stop information and analysis source for pipeline, products, clinical trials, drug delivery technologies, deals and acquisitions, company financials, venture capital investments, product sales, pharmaceutical services, news, patents and more….


    Pharmiweb

    Supporters
    http://www.pharmiweb.com

    Established in October 2003, PharmiWeb Solutions is an energetic, innovative provider of web-based solutions for the pharmaceutical sector, with customers such as AstraZeneca, Roche, Servier Laboratories, and Merck With solutions in three key areas: Online Publishing, e-Business and Mobile Computing, we deliver connectivity – between people and applications – unlocking islands of data and knowledge. We own some of the sector’s most innovative Online Publications: PharmiWeb.com, HospitalPharma.com and Detail-Direct.com. We are actively developing solutions for Mobile Computing platforms. For example, our PharmiTabTM e-pharmacy solution runs real-time patient data and prescribing transactions in a busy hospital environment, on a TabletPC, wireless client/server platform. e-Business solutions range from e-Detailing, to Online Market Research, all designed to increase reach, increase sales, and to reduce administration and costs.


    Gene Therapy Net

    Supporters
    http://www.genetherapynet.com

    Gene Therapy Net is the information resource for basic and clinical research in gene therapy, and the site serves as a network in the exchange of gene therapy information and breaking news items. Visitors can keep track of the latest scientific papers, conference announcements, gene therapy jobs, regulations and guidelines


    Biocompare

    Supporters
    http://www.biocompare.com

    Biocompare.com is the leading resource for up-to-date product information, product reviews, and new technologies for life scientists. Biocompare combines an in-depth knowledge of life science products and new technologies with the power of the Internet to offer scientists the most dynamic, relevant, and innovative media-based marketplace for life science information.

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    Copthorne Tara Hotel

    Scarsdale Place
    Kensington
    London W8 5SR
    United Kingdom

    Copthorne Tara Hotel

    The Copthorne Tara Hotel London Kensington is an elegant contemporary four-star hotel in prestigious Kensington, located just a two minutes walk from High Street Kensington underground station, making exploring easy. The hotel offers well-appointed and comfortable guest rooms combining Standard, Superior and Club accommodation. Club rooms offer iconic views over the city and include Club Lounge access for complimentary breakfast and refreshments. Guests can sample the authentic Singaporean, Malaysian and Chinese cuisine at Bugis Street, traditional pub fare at the Brasserie Restaurant & Bar or relax with a delicious drink at West8 Cocktail Lounge & Bar.

    The Copthorne Tara Hotel boasts 745 square meters of flexible meeting space, consisting of the Shannon Suite and the Liffey Suite, ideal for hosting conferences, weddings and social events. Facilities include access to the business centre 24 hours a day, fully equipped fitness room, gift shop, theatre desk and Bureau de Change. With ample onsite parking outside the London congestion charge zone and excellent transport links via Heathrow Airport, the hotel is the perfect location for business or leisure stays. The hotel is within close proximity to the shops of High Street Kensington, Knightsbridge and Westfield London, Olympia Conference Centre, Royal Albert Hall, Kensington Palace and Hyde Park.

     

    HOTEL BOOKING FORM

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    WHAT IS CPD?

    CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

    ‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

    CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

    Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

    CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.

    CPD AND PROFESSIONAL INSTITUTES

    There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

    For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

    CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.

    TYPICAL CPD SCHEMES AND RECORDING OF CPD (CPD points and hours)

    Professional bodies and Institutes CPD schemes are either structured as ‘Input’ or ‘Output’ based.

    ‘Input’ based schemes list a precise number of CPD hours that individuals must achieve within a given time period. These schemes can also use different ‘currencies’ such as points, merits, units or credits, where an individual must accumulate the number required. These currencies are usually based on time i.e. 1 CPD point = 1 hour of learning.

    ‘Output’ based schemes are learner centred. They require individuals to set learning goals that align to professional competencies, or personal development objectives. These schemes also list different ways to achieve the learning goals e.g. training courses, seminars or e:learning, which enables an individual to complete their CPD through their preferred mode of learning.

    The majority of Input and Output based schemes actively encourage individuals to seek appropriate CPD activities independently.

    As a formal provider of CPD certified activities, SMI Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.

    GLOBAL CPD

    Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

    CPD Certificates

    We can provide a certificate for all our accredited events. To request a CPD certificate for a conference , workshop, master classes you have attended please email events@smi-online.co.uk

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    Opening Hours: 9.00 - 17.30 (local time)
    SMi Group Ltd, 1 Westminster Bridge Road, London, SE1 7XW, United Kingdom
    Tel: +44 (0) 20 7827 6000 Fax: +44 (0) 20 7827 6001
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