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SMi’s 22nd Annual Conference
Pain Therapeutics
4 - 5 May, 2022 | London, UK
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To register your interest or to get involved please contact:Join Europe’s leading Pain Therapeutics Conference, to explore the cutting-edge research of novel therapeutic targets in the pipeline of leading pharmaceutical companies and to discuss solutions for the challenges of clinical trial design and conduct.


The 22nd annual conference will cover the leading advances in pain therapeutics, exploring late development clinical trials, novel treatments for chronic conditions, technology collaboration treatments, using VR and Medical Devices that carry out non-invasive nerve stimulation. Industry leaders will uncover the latest advancements in the field, highlighting the use of opioids and the future for cannabinoids within the pain therapeutics field. Furthermore, policy experts will provide an essential regulatory perspective for this year’s agenda, providing an exciting and comprehensive insight into the pain therapeutics market.


New case studies and regulatory perspectives will bring together the challenges and successes of both pre-clinical and clinical development to equip you with the necessary knowledge to advance the pain therapeutic industry.

 

This workshop will give you an insight into the molecular and cellular pathophysiology of pain resolution. With a highlight
on the acute inflammatory response, protection against pain chronification and an analysis of pain trajectories in humans reporting acute back pain. There will also be specific examples in the treatment of pathological pain via neuroimmune regulation and the resolution of acute
pain by active molecular processes and the production of specialized pro-resolving medicators (SPM’s). There will also
be a highlight on pain as a persistent feature of rheumatoid arthritis.

This workshop will allow you to:

  • Develop your knowledge of acute pain
  • Interact with research professionals and network with industry specialists
  • Further your understanding of rheumatoid arthritis
  • Discuss the active process of resolving acute pain

Chief Executive Officer, Chief Scientific Officers, Chief Medical Officers, Managing Directors, CEO, Head of Department, Principal Research Scientists, Clinical lead, Clinical Operations in the following fields:

Pain and Migraine
Inflammation
Chronic Pain
Neuropathic Pain
Analgesic pre-clinical development
Anaesthesia and Pain Management
CNS clinical trials
Ion Channel Pharmacology
Pharmacology Intelligence
Translational science
Drug development
Exploratory development
 

Workshop programme

13:00 Registration and Coffee

13:30 Opening Remarks and Introductions

Luda Diatchenko

Luda Diatchenko, Canada Research Chair in Human Pain Genetics, McGill University

Julio Reinecke

Julio Reinecke, Chief Scientific Officer and Co-Founder, Orthogen A G

Peter Wehling

Peter Wehling, CEO and Founder, Orthogen A G

Ru-Rong Ji

Ru-Rong Ji, Professor in Anesthesiology, Distinguished Professor of Anesthesiology, Professor in Neurobiology, Professor in Cell Biology, School of Medicine,, Duke Neurobiology

13:40 Acute Inflammatory Response via Neutrophil Activation Protects Against Pain Chronification

Luda Diatchenko

Luda Diatchenko, Canada Research Chair in Human Pain Genetics, McGill University

  • The investigation of the pathophysiological mechanisms underlying the transition from acute to chronic low back pain (LBP) at the transcriptome-wide level in peripheral immune cells 
  • Dynamic transcriptional changes over three months in LBP participants with resolved pain
  • Long lasting effects of treatment with a steroidal or non-steroidal anti-inflammatory drug (NSAID) at acute stage of animal pain assay
  • Analysis of analgesic-depend pain trajectories of human subjects reporting acute back pain in UK Biobank
     
  • 14:20 Targeting GPR37 for the resolution of pathological pain via neuroimmune regulation

    Ru-Rong Ji

    Ru-Rong Ji, Professor in Anesthesiology, Distinguished Professor of Anesthesiology, Professor in Neurobiology, Professor in Cell Biology, School of Medicine,, Duke Neurobiology

  • The resolution of acute pain requires an active molecular process and production of specialized pro-resolving mediators (SPMs), including resolvins, protectins, maresins, and lipoxins
  • Neuroprotectin D1 (NPD1) produces potent pain relief in animal models of inflammatory, neuropathic, and cancer pain
  • Computer simulations identify new ligands of GPR37 including NPD1. Furthermore, GPR37 agonists control inflammation and protect against septic death in animal models of infections
  • Findings suggest that the NPD1/GPR37 axis regulates the resolution of pain and inflammation via both neuronal and non-neuronal regulations
  • Resolution–based therapeutic strategies, including pharmacological and non-pharmacological ones, for the resolution of pain
  • 15:00 Afternoon Tea

    15:30 Chronic pain therapies targeting reestablishment of tissue homeostasis

  • Chronic pain therapies targeting reestablishment of tissue homeostasis aim alleviating local overshooting cytokines, ROS, and energy supply rather than blocking receptors or otherwise inhibit nerve function
  • Such strategies are attractive for chronic pain such as chronified nerve root inflammation or musculoskeletal pain
  • Such an approach is feasible by mesenchymal stem cell secretomes but also by a whole blood secretome autologous conditioned serum (ACS).
  • Several examples of ACS performed in chronified inflammatory pain of various origin will be discussed.
     
  • Julio Reinecke

    Julio Reinecke, Chief Scientific Officer and Co-Founder, Orthogen A G

    Peter Wehling

    Peter Wehling, CEO and Founder, Orthogen A G

    16:10 Future outlook and open discussion

  • An overview of the educational objectives within this workshop
  • Group discussion on the current state of targeting pain resolution versus inhibition of pain state
  • Question and Answer opportunity
  • Luda Diatchenko

    Luda Diatchenko, Canada Research Chair in Human Pain Genetics, McGill University

    Julio Reinecke

    Julio Reinecke, Chief Scientific Officer and Co-Founder, Orthogen A G

    Peter Wehling

    Peter Wehling, CEO and Founder, Orthogen A G

    Ru-Rong Ji

    Ru-Rong Ji, Professor in Anesthesiology, Distinguished Professor of Anesthesiology, Professor in Neurobiology, Professor in Cell Biology, School of Medicine,, Duke Neurobiology

    16:50 Closing Remarks

    Luda Diatchenko

    Luda Diatchenko, Canada Research Chair in Human Pain Genetics, McGill University

    Julio Reinecke

    Julio Reinecke, Chief Scientific Officer and Co-Founder, Orthogen A G

    Peter Wehling

    Peter Wehling, CEO and Founder, Orthogen A G

    Ru-Rong Ji

    Ru-Rong Ji, Professor in Anesthesiology, Distinguished Professor of Anesthesiology, Professor in Neurobiology, Professor in Cell Biology, School of Medicine,, Duke Neurobiology

    17:00 End of Workshop

    +

    VENUE

    Copthorne Tara Hotel

    Scarsdale Place, Kensington, London, United Kingdom

    The Copthorne Tara Hotel London Kensington is an elegant contemporary four-star hotel in prestigious Kensington, located just a two minutes walk from High Street Kensington underground station, making exploring easy. The hotel offers well-appointed and comfortable guest rooms combining Standard, Superior and Club accommodation. Club rooms offer iconic views over the city and include Club Lounge access for complimentary breakfast and refreshments. Guests can sample the authentic Singaporean, Malaysian and Chinese cuisine at Bugis Street, traditional pub fare at the Brasserie Restaurant & Bar or relax with a delicious drink at West8 Cocktail Lounge & Bar.

    The Copthorne Tara Hotel boasts 745 square meters of flexible meeting space, consisting of the Shannon Suite and the Liffey Suite, ideal for hosting conferences, weddings and social events. Facilities include access to the business centre 24 hours a day, fully equipped fitness room, gift shop, theatre desk and Bureau de Change. With ample onsite parking outside the London congestion charge zone and excellent transport links via Heathrow Airport, the hotel is the perfect location for business or leisure stays. The hotel is within close proximity to the shops of High Street Kensington, Knightsbridge and Westfield London, Olympia Conference Centre, Royal Albert Hall, Kensington Palace and Hyde Park.

     

    A number of our clients have been approached by third party organisations offering to book hotel rooms. We would advise that you do not book through them as they are not representing the SMi Group. SMi Group books all hotel rooms directly. If you are approached by a third party organisation then please contact us before making any bookings. If you have already booked a hotel room using a third party organisation, we would highly recommend contacting the hotel you were booked into to ensure a booking has been made for you. We would also advise you to please check the terms and conditions of the booking carefully.
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    Copthorne Tara Hotel

    Scarsdale Place
    Kensington
    London W8 5SR
    United Kingdom

    Copthorne Tara Hotel

    The Copthorne Tara Hotel London Kensington is an elegant contemporary four-star hotel in prestigious Kensington, located just a two minutes walk from High Street Kensington underground station, making exploring easy. The hotel offers well-appointed and comfortable guest rooms combining Standard, Superior and Club accommodation. Club rooms offer iconic views over the city and include Club Lounge access for complimentary breakfast and refreshments. Guests can sample the authentic Singaporean, Malaysian and Chinese cuisine at Bugis Street, traditional pub fare at the Brasserie Restaurant & Bar or relax with a delicious drink at West8 Cocktail Lounge & Bar.

    The Copthorne Tara Hotel boasts 745 square meters of flexible meeting space, consisting of the Shannon Suite and the Liffey Suite, ideal for hosting conferences, weddings and social events. Facilities include access to the business centre 24 hours a day, fully equipped fitness room, gift shop, theatre desk and Bureau de Change. With ample onsite parking outside the London congestion charge zone and excellent transport links via Heathrow Airport, the hotel is the perfect location for business or leisure stays. The hotel is within close proximity to the shops of High Street Kensington, Knightsbridge and Westfield London, Olympia Conference Centre, Royal Albert Hall, Kensington Palace and Hyde Park.

     

    HOTEL BOOKING FORM

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    WHAT IS CPD?

    CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

    ‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

    CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

    Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

    CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.

    CPD AND PROFESSIONAL INSTITUTES

    There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

    For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

    CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.

    TYPICAL CPD SCHEMES AND RECORDING OF CPD (CPD points and hours)

    Professional bodies and Institutes CPD schemes are either structured as ‘Input’ or ‘Output’ based.

    ‘Input’ based schemes list a precise number of CPD hours that individuals must achieve within a given time period. These schemes can also use different ‘currencies’ such as points, merits, units or credits, where an individual must accumulate the number required. These currencies are usually based on time i.e. 1 CPD point = 1 hour of learning.

    ‘Output’ based schemes are learner centred. They require individuals to set learning goals that align to professional competencies, or personal development objectives. These schemes also list different ways to achieve the learning goals e.g. training courses, seminars or e:learning, which enables an individual to complete their CPD through their preferred mode of learning.

    The majority of Input and Output based schemes actively encourage individuals to seek appropriate CPD activities independently.

    As a formal provider of CPD certified activities, SMI Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.

    GLOBAL CPD

    Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

    CPD Certificates

    We can provide a certificate for all our accredited events. To request a CPD certificate for a conference , workshop, master classes you have attended please email events@smi-online.co.uk

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