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SMi is proud to present the New RNA Therapeutics Focus Day - Oligonucleotide Delivery Systems.


Introducing the only RNA therapeutics conference to hold a full day exploring alternatives to oligonucleotide delivery systems. With the global antisense and RNA therapeutics market size is expected to expand at a compound annual growth rate (CAGR) of 8.6% between 2019 and 2025, projected to reach $1.81 billion, this focus day will assess the growing need for research and development of novel delivery approaches to expand the current delivery methods in today's market.


In conjunction with Europe’s leading RNA therapeutics conference, we will explore new discoveries in novel drug delivery through case studies, regulatory outlooks and industry examples to give a comprehensive overview of the oligonucleotide delivery space.


This focus day offers you peer-to-peer networking with Global Product Managers, Heads of Drug Development, Senior Directors, Heads of Research and Development and many more.


We look forward to welcoming you to the conference in February.


Early registration is strongly advised to avoid disappointment.
 

Key Job Titles include:

Research & Development Directors/Managers/Scientists
Heads of Clinical Development
Heads of Pre-Clinical Development
Head of RNA Biology
Head of RNA Formulation and Drug Delivery
Head of Pre-clinical R&D
Head of New Modalities
Head of Discovery
Senior Scientists
Chief Scientific Officers
Chief Medical Officers


Global Presence:

Attendees from all over the world attend our events, gain hands on insight from representatives from UK, Europe and USA.
 

Accanis Therapeutics; Advanced Cell Diagnostics – A Bio-Techne Brand; Aescap 2.0; Alnylam Pharmaceuticals UK & Ireland; AmpTec GmbH; Aseptic Technologies SA; AstraZeneca; Bachem AG; BianoGMP; BioNTech IMFS GmbH; BioNTech RNA Pharmaceuticals; Boehringer Ingelheim Pharma GmbH & Co. KG; Calithera Biosciences; CEPI - Coalition for Epimemic Prepardness Innovation; Chemgenes Corporation; Curevac Ag; Dicerna Therapeutics.; Duke University School of Medicine; Ethris GmbH; Exicure Inc.; F.Hoffmann-La Roche AG; GSK; Horizon Discovery; InteRNA Technologies BV; Intertek; Lipocalyx; MedImmune; MHRA; MiNA Therapeutics; N4 Pharma UK Limited; New England Biolabs; NHS Blood and Transplant Authority; Nitto Avecia; NOF Europe GmbH; Nouscom SRL; ProQR Therapeutics; RCSI; RCSI Royal College of Surgeons in Ireland,; RNA Medco; ROCHE; Roche Diagnostics Deutschland GmbH; Roche Innovation Center; Russell Publishing Ltd; Sanofi; Sanofi-Aventis Deutschland GmbH; Takeda Development Centre Europe Ltd.; TCR Solutions; The Italian Institute of Technology; The RNA Medicines Company; Thermo Fisher Scientific; University Medicine Mainz Hospital; University Of Portsmouth; University Of Surrey; Yuria Pharma;
 

Focus Day programme

8:30 Registration & Coffee

9:00 Chair's Opening Remarks

Shalini Andersson

Shalini Andersson, Chief Scientist New Therapeutic Modalities, AstraZeneca
View Bio

9:10 Optimizing Nanoparticle mediated delivery of siRNAs to treat cancer and fibrosis

David Evans

David Evans, Chief Scientific Officer, Sirnaomics, Inc
View Bio

• Presenting a polypeptide nanoparticle mediated delivery system for siRNA therapeutics to treat cancer and fibrosis
• The benefits of the ability to deliver multiple siRNAs within the tumour microenvironment will be discussed
• Leveraging this capability to improve outcomes with Immune Checkpoint inhibitors
• Improved GMP manufacturing approaches using microfluidics for clinical development
 

9:50 Development of a light-triggered liposomes for intracellular oligonucleotide delivery to the retina

Enrico Mastrobattista

Enrico Mastrobattista, Professor of Pharmaceutical Biotechnology & Delivery, Utrecht University
View Bio

• Inherent challenges in oligonucleotide-based drug delivery modes
• Achieving an efficient and safe intracellular liposomal delivery system activated by light
• Discuss the methods, results and opportunities
• Discuss an ex vivo perfused eye model for ocular delivery of ON
 

10:30 Morning Coffee

11:00 Design of Safe and Potent Nucleic Acid Therapeutics

Pete Lutwyche

Pete Lutwyche, CTO, Genevant Sciences
View Bio

• Review of important elements of lipid nanoparticle technology
• Abrogation of common NA-LNP tolerability concerns
• Optimization of systemic mRNA therapeutics
 

11:40 Addressing the challenge of chronic dosing via traditional LNP-based delivery for mRNA therapeutics

Shalini Andersson

Shalini Andersson, Chief Scientist New Therapeutic Modalities, AstraZeneca
View Bio

• Clinical appeal of lipid nanoparticle delivery systems and other competing modes of delivery
• Challenges in production and screening of LNP candidates for effective translation to biotherapeutics
• Complications of chronic dosing and acceptable tolerability profiles
• Showcasing the development of a tolerable subcutaneous administration of mRNA via functionalized LNPs
 

12:20 Networking Lunch

13:20 Exploring the development and progress of BioNTech mRNA therapeutic delivery platforms

Heinrich Haas

Heinrich Haas, VP RNA Formulation and Drug Developement , BioNTech RNA Pharmaceuticals
View Bio

14:00 Aiming at delivering RNA to tumors using intra-venous injections

Steve Pascolo

Steve Pascolo, Founder and CEO, Miescher Pharma GmbH
View Bio

• Types of anti-cancer RNA requiring delivery to tumors
• Reported and original formulations: biodistribution in tumor bearing mice
• In vivo efficacy of formulated anti-cancer RNA

14:40 Overcoming lung barriers to siRNA delivery in cystic fibrosis through tailored lipid/polymer hybrid nanoparticles

Francesca Ungaro

Francesca Ungaro, Associate Professor, University Of Napoli Federico Ii
View Bio

• Non-Cellular and cellular barriers to inhaled siRNA in cystic fibrosis
• Strategies to engineer nanoparticles to overcome lung barriers
• In vitro and in vivo efficacy of inhalable hybrid lipid/polymer nanoparticles for siRNA delivery in cystic fibrosis
 

15:20 Afternoon Tea

15:50 Advanced microscopy methods to monitor RNA encapsulation and nanoparticle stability in biological environments

Katrien Remaut

Katrien Remaut, Associate Professor, Ghent University
View Bio

• Fluorescence correlation spectroscopy (FCS) to monitor RNA (mRNA, siRNA) encapsulation in nanoparticles
• RNA release and degradation in biological fluids
• Intracellular dissociation and degradation kinetics
 

16:30 Panel Discussion: Discussing the ongoing challenges of oligonucleotide delivery

Heinrich Haas

Heinrich Haas, VP RNA Formulation and Drug Developement , BioNTech RNA Pharmaceuticals
View Bio

• Questions around conjugation versus encapsulation; benefits and drawbacks
• Details and concerns behind the interactions between payloads and delivery vehicles
• Factors influencing the ratio between payload and delivery vehicle – what is an optimal ratio?
• Lipid-based encapsulation versus other nanoparticles
• Regulatory implications regarding production and quality; CMC and manufacturing
• Where is the next success in extrahepatic delivery?
 

17:30 Chair’s Closing Remarks and Close of Focus Day

+

VENUE

Copthorne Tara Hotel

Scarsdale Place, Kensington, London, United Kingdom

The Copthorne Tara Hotel London Kensington is an elegant contemporary four-star hotel in prestigious Kensington, located just a two minutes walk from High Street Kensington underground station, making exploring easy. The hotel offers well-appointed and comfortable guest rooms combining Standard, Superior and Club accommodation. Club rooms offer iconic views over the city and include Club Lounge access for complimentary breakfast and refreshments. Guests can sample the authentic Singaporean, Malaysian and Chinese cuisine at Bugis Street, traditional pub fare at the Brasserie Restaurant & Bar or relax with a delicious drink at West8 Cocktail Lounge & Bar.

The Copthorne Tara Hotel boasts 745 square meters of flexible meeting space, consisting of the Shannon Suite and the Liffey Suite, ideal for hosting conferences, weddings and social events. Facilities include access to the business centre 24 hours a day, fully equipped fitness room, gift shop, theatre desk and Bureau de Change. With ample onsite parking outside the London congestion charge zone and excellent transport links via Heathrow Airport, the hotel is the perfect location for business or leisure stays. The hotel is within close proximity to the shops of High Street Kensington, Knightsbridge and Westfield London, Olympia Conference Centre, Royal Albert Hall, Kensington Palace and Hyde Park.

 

A number of our clients have been approached by third party organisations offering to book hotel rooms. We would advise that you do not book through them as they are not representing the SMi Group. SMi Group books all hotel rooms directly. If you are approached by a third party organisation then please contact us before making any bookings. If you have already booked a hotel room using a third party organisation, we would highly recommend contacting the hotel you were booked into to ensure a booking has been made for you. We would also advise you to please check the terms and conditions of the booking carefully.
HOTEL BOOKING FORM

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Copthorne Tara Hotel

Scarsdale Place
Kensington
London W8 5SR
United Kingdom

Copthorne Tara Hotel

The Copthorne Tara Hotel London Kensington is an elegant contemporary four-star hotel in prestigious Kensington, located just a two minutes walk from High Street Kensington underground station, making exploring easy. The hotel offers well-appointed and comfortable guest rooms combining Standard, Superior and Club accommodation. Club rooms offer iconic views over the city and include Club Lounge access for complimentary breakfast and refreshments. Guests can sample the authentic Singaporean, Malaysian and Chinese cuisine at Bugis Street, traditional pub fare at the Brasserie Restaurant & Bar or relax with a delicious drink at West8 Cocktail Lounge & Bar.

The Copthorne Tara Hotel boasts 745 square meters of flexible meeting space, consisting of the Shannon Suite and the Liffey Suite, ideal for hosting conferences, weddings and social events. Facilities include access to the business centre 24 hours a day, fully equipped fitness room, gift shop, theatre desk and Bureau de Change. With ample onsite parking outside the London congestion charge zone and excellent transport links via Heathrow Airport, the hotel is the perfect location for business or leisure stays. The hotel is within close proximity to the shops of High Street Kensington, Knightsbridge and Westfield London, Olympia Conference Centre, Royal Albert Hall, Kensington Palace and Hyde Park.

 

HOTEL BOOKING FORM

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WHAT IS CPD?

CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.

CPD AND PROFESSIONAL INSTITUTES

There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.

TYPICAL CPD SCHEMES AND RECORDING OF CPD (CPD points and hours)

Professional bodies and Institutes CPD schemes are either structured as ‘Input’ or ‘Output’ based.

‘Input’ based schemes list a precise number of CPD hours that individuals must achieve within a given time period. These schemes can also use different ‘currencies’ such as points, merits, units or credits, where an individual must accumulate the number required. These currencies are usually based on time i.e. 1 CPD point = 1 hour of learning.

‘Output’ based schemes are learner centred. They require individuals to set learning goals that align to professional competencies, or personal development objectives. These schemes also list different ways to achieve the learning goals e.g. training courses, seminars or e:learning, which enables an individual to complete their CPD through their preferred mode of learning.

The majority of Input and Output based schemes actively encourage individuals to seek appropriate CPD activities independently.

As a formal provider of CPD certified activities, SMI Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.

GLOBAL CPD

Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

CPD Certificates

We can provide a certificate for all our accredited events. To request a CPD certificate for a conference , workshop, master classes you have attended please email events@smi-online.co.uk

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