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Building on the sell-out success of the launch event, SMi Group is delighted to announce the return of 3D Cell Culture, taking place on 21st and 22nd of February 2018, in London UK.

Whilst still in its infancy, 3D Cell Culture is rapidly growing with not only a widespread reach that can be seen across a number of different fields such as 3D bioprinting and microfluidics, but also with incredible potential for industrial application. The 2nd annual conference will explore these overlapping areas and will also update delegates on pioneering developments in surrounding topics such as disease models, organoids, organ-on-a-chip technologies and iPSC advances.
 

Attendee testimonials from 2017:

“Very good presentations and a few outstanding ones...I made some useful contacts” Asterand Bioscience
“The conference was wonderfully organised” Novartis
“Good start, love to see the event occur again” Thermo Fisher Scientific
 

  • Uncover the biology of human neurodevelopment diseases in 3D by merging cutting edge technologies in CRISPR editing and single cell sequencing
  • Take a 3D biology approach to overcome challenges for cell based screening with exclusive insight into electrospun micro-scaffold based biology
  • Develop strategies for optimising placement of cells in printing by identifying key developments in the overlap of 3D bioprinting and 3D cell culturing
  • Identify new approaches to predictive substance testing through innovative case study insight into multi-organ-chip technology
  • Benefit from an agenda tailored towards driving clinical development through ground breaking case studies on the Zika virus and tuberous sclerosis
  • Adapt current microfluidic culture methods into large scale manufacturing


 

Join us this year to network with our growing community. Previous attendees include:

Aber; Aber Instruments Ltd; Adaptimmune Ltd; Aptuit (Verona) S.r.l; Asterand Bioscience; AstraZeneca; Barts Cancer Institute; Bial; Biogelx Ltd; BioTek Instruments Ltd.; Boehringer-Ingelheim; Cellesce Limited; Cellon S.A; Cellular Dynamics International; Corning; Department of Craniofacial Development and Stem Cell Biology; Durham University; EPISKIN SA; Epithelix; F. Hoffmann-La Roche AG; F. Hoffmann-La Roche Ltd.; GE Healthcare; GlaxoSmithKline; GSK; Hubrecht Institute; Immunocore Ltd; Imperial College; Imperial College London; Jellagen Pty Ltd; Kings College London; King's College London; Kings College School Of Medicine And Dentistry; Lonza Incorporated; Medical Research Council; MHRA; Microduits GmbH; Neem Biotech Ltd; Nexcelom; NIFES; Novartis Institutes For Biomedical Research; Novartis Pharmaceuticals; Pfizer; Plasticell Ltd; ProDigest; Progen Biotechnik GmbH; Reinnervate; Roche Diagnostics ; Samedan Ltd; Sanofi; Sigma Aldrich; Stemtek Therapeutics; tebu-bio; Technologie Servler; The Scripps Research Institute; Thermo Fisher Scientific; TissUse GmbH; Unilever Research Colworth; university surrey; Ventana Medical System, Inc + more!

Conference programme

8:30 Registration & Coffee

9:00 Chairman's Opening Remarks

Stefan Przyborski

Stefan Przyborski, Professor of Cell Technology, University of Durham

9:10 3D Cell Culture – A Rapidly Developing Series of Technologies Enabling the Evolution of Complex Models of Human Tissues and In Vitro Assays

Stefan Przyborski

Stefan Przyborski, Professor of Cell Technology, University of Durham

  • 3D vs 2D cell culture – the similarities and differences between both methods;
  • Demand for 3D cell culture;
  • No one solution - alternative techniques: organoids, spheroids, hydrogels and scaffolds;
  • Examples of current applications –simple 3D cultures to engineering complex tissues;
  • Case example – building layered tissue structures to model the anatomy and physiology of native counterparts;
  • New developments in 3D cell culture and related technologies
     
  • 9:50 Electrospun micro-scaffold based biology – a 3-D biology approach to overcome many challenges for well-based screening

    Gary Allenby

    Gary Allenby, Business Development Director and Chief Scientific Officer, Aurelia Bioscience

    Electrospun scaffold material is used in regenerative medicine to grow, differentiate and deliver stem cells into patients – we have developed practical approaches to use this material for 3-D screening purposes
    Our primary cells, differentiated stem cells and recombinant cells grow on and into micro-scaffold islands, effectively 3-D micro-tissues on a matrix in micro-wells and in media
    By incorporating iron particles into the scaffold material, we can physically manipulate the micro-scaffolds with magnetism, moving these around wells of plates and tubes in culture
    We will show data from a number of assay readouts to exemplify the simplicity of the approach for cell-based phenotypic screening together with advantages of this approach for assay biology

    10:30 Morning Coffee

    11:00 Merging CRISPR-editing and single cell sequencing technologies to uncover the biology of human neurodevelopmental diseases in 3D: case studies with Zika virus and tuberous sclerosis

    Max Salick

    Max Salick, Postdoctoral Researcher, Novartis Institutes For Biomedical Research

  • CRISPR-engineered human stem cell lines mimic disease phenotypes during 3D cerebral organoid differentiation
  • Selective removal of target genes in cerebral organoids reveals the biology of Zika virus infection
  • Whole-genome CRISPR screens enable the discovery of new proteins linked to tropism of emerging infectious diseases
  • Single cell sequencing allows researchers to investigate cell-type specific effects of mutations, treatments, or other perturbations in complex 3D tissues
  •  

    11:40 The potential of advanced cell culture models for the understanding of disease and compound testing

    Vitor Santo

    Vitor Santo, Senior Scientist, Immunocore

  • There is an increasing demand for the application of more predictable cell models in drug discovery. These models should be able to reflect human tissue properties and functionality more faithfully, enabling to recapitulate in vitro certain features of tissue microenvironment.
  • Pathophysiological-relevant cell models require the existence of cell-cell, cell-extracellular matrix and soluble factors to caption tissue complexity at a certain extent.
  • Increase in complexity of model design must be accompanied by the application of more advanced characterization tools and read-outs.
     
  • 12:20 Networking Lunch

    13:30 Direct tissue engineering approaches for regenerative biology and medicine

    Suwan Jaysinghe

    Suwan Jaysinghe, Professor of Bioengineering, University College London

  • Technological application in cell culture and expansion
  • Biological model development
  • Tissues development in a dish, for drug development and screening etc.
  • Reconstruction of tissues for repair, replacement and rejuvenation
  • 14:10 Can 3D cell culture improve the prediction of hepatotoxicity in early phase screening?

    Christopher Schofield

    Christopher Schofield, Investigator, GSK

  • Development of a 3D primary human hepatocyte in vitro model
  • Comparison to current 2D and other complex in vitro models
  • Industrialisation for compound screening and further characterisation
  • The results of a validation compound set
  • 14:50 Afternoon Tea

    15:20 The optimisation of tissue specific cell-based disease models and assay development

    16:00 The UKRMP – a national strategic initiative

    David Pan

    David Pan, Programme Manager (Regenerative Medicine), UK Regenerative Medicine Platform

  • What are the key challenges for regenerative medicine?
  • What is the ambition and of the UK’s strategic approach?
  • Overview of developments, current standings and forward plans
  • 16:40 Chairman’s Closing Remarks and Close of Day One

    8:30 Registration & Coffee

    9:00 Chairman's Opening Remarks

    Gary Allenby

    Gary Allenby, Business Development Director and Chief Scientific Officer, Aurelia Bioscience

    9:10 The overlap of 3D bioprinting and 3D cell culturing in Cancer Research

    Nicholas Leslie

    Nicholas Leslie, Professor, Heriot-Watt University

  • Overview of 3D bioprinting
  • The reliance of 3D bioprinting on spheroid models and cell organisation
  • How to achieve correct architecture, based on different disease models
  • How improving placement of cells in printing can translate into improved model
  • The synonymy of 3D bioprinting and 3D cell culture
     
  • 9:50 Multi-Organ-Chip technology: A completely new approach to predictive substance testing

    Reyk Horland

    Reyk Horland, Head of Business Development, TissUse GmbH

  • Definition and overview of Organ-on-a-Chip (OOC) systems
  • Scientific concept, design principles and fabrication of OOC
  • Case studies on industrial applications off OOC
  • Qualification and validation of OOC
  • Roadmap towards individual “Patients-on-a-Chip”
  • 10:30 Morning Coffee

    11:00 Complex co-cultured spheroids to validate tumour models in microfluidic devices

    Tudor  Petreus

    Tudor Petreus, PostDoctoral Researcher, AstraZeneca

  • Overview on the tumour-on-chip models
  • Development of in vitro prevascularized minitumours – current progress and optimization
  • Prevascularized tumour models in cancer research
  • 11:40 Development of processing platforms for allogeneic cell therapy manufacturing: Expansion of pluripotent stem cells in 2D and 3D culture systems

    Ricardo Baptista

    Ricardo Baptista, Lead Scientist Process Development, Cell and Gene Therapy Catapult

  • BULLET POINTS TO BE CONFIRMED
  • 12:20 Networking Lunch

    13:30 3D cellular models for drug safety assessment: an industry perspective

    Stefan Kustermann

    Stefan Kustermann, Lab Head, Roche Pharma Schweiz AG

     

  • There is a strong need for complex in vitro models for drug safety assessment recapitulating human physiology to a high degree
  • This is supported by an ever increasing complexity of modalities and targets with a strong need for human in vitro models
  • Novel human 3D cellular models will be presented and their impact for drug safety assessment will be discussed
  • 14:10 How laws of nature should guide the development of 3D cell culture for regenerative medicine

    Patrick Kugelmeier

    Patrick Kugelmeier, Director of Science, Kugelmeiers

  • We are learning the language of life. Stem cell communication principles.
  • First principle reasoning – how stem cell communication principles influence medical device development
  • Challenges on the way to the largest evolution of medicine in history
  • 14:50 Afternoon Tea

    15:20 3D imaging of culture models and how to overcome the current challenges of conventional imaging techniques

    16:00 An overview of the potential of 3D cell culture: how looking to the future of the field could influence the advancements of today

    16:40 Chairman’s Closing Remarks and Close of Day Two

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    Holiday Inn Kensington Forum

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    WHAT IS CPD?

    CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

    ‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

    CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

    Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

    CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.

    CPD AND PROFESSIONAL INSTITUTES

    There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

    For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

    CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.

    TYPICAL CPD SCHEMES AND RECORDING OF CPD (CPD points and hours)

    Professional bodies and Institutes CPD schemes are either structured as ‘Input’ or ‘Output’ based.

    ‘Input’ based schemes list a precise number of CPD hours that individuals must achieve within a given time period. These schemes can also use different ‘currencies’ such as points, merits, units or credits, where an individual must accumulate the number required. These currencies are usually based on time i.e. 1 CPD point = 1 hour of learning.

    ‘Output’ based schemes are learner centred. They require individuals to set learning goals that align to professional competencies, or personal development objectives. These schemes also list different ways to achieve the learning goals e.g. training courses, seminars or e:learning, which enables an individual to complete their CPD through their preferred mode of learning.

    The majority of Input and Output based schemes actively encourage individuals to seek appropriate CPD activities independently.

    As a formal provider of CPD certified activities, SMI Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.

    GLOBAL CPD

    Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

    CPD Certificates

    We can provide a certificate for all our accredited events. To request a CPD certificate for a conference , workshop, master classes you have attended please email events@smi-online.co.uk

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