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SMi is proud to announce the return of their 14th annual Controlled Release event to London in 2017!


A global pharmaceutical excipients market report states oral solid dosage formulations are expected to significantly increase uptake due to to the ease of consumption by patients globally. Oral application type segment is expected to increase from US$ 3,327.8 Mn in 2015 to US$ 5,094.2 Mn by the end of 2021.*

The prime drivers of the market will include increased demand for sustained-release and controlled-release formulations, especially in oral applications, and increased demand for generics. SMi’s Controlled Release 2017 event will guarantee practical and critical discussions on the latest innovation in controlled release drug delivery. The conference will strengthen understanding in the latest regulatory landscape.
 

* http://www.medgadget.com/2016/09/analyze-pharmaceutical-excipients-market-demands-by-2021.html
 

 

• Listen to FDA evaluate generic drug development
• Novartis optimise the success of biopharmaceutical
approaches for controlled release delivery
• Can lipid suspensions improve oral bioavailability?
Answers from Janssen
• Insights into the opportunities and limitations to
improving solubility and bioavailability with Actelion
• Hear InnoCore Pharmaceuticals discuss microparticles
and hydrogels for parenteral drug delivery

Action Duchenne; AstraZeneca; Capsugel; Chemo Iberica; Colorcon Ltd; Critical Pharmaceuticals Limited; Debiopharm Research & manufacturing SA; Diurnal; evonik; FDA; Formuli; GlaxoSmithKline; GW Pharmaceuticals Ltd; H Lundbeck A/S; Handok Pharmaceuticals Co. Ltd; Hovione; Lucideon; MedImmune Inc.; medincell; Merck; Merck Research Laboratories; MHRA; Novartis Pharma AG; Novo Nordisk A / S; Onxeo; pSivida Corp.; Sotax A; Sotax Corp; SPS Pharma Services; Tecrea Ltd; Triskelion BV; University Of Oxford; university of pavia; University Of Strathclyde;

Conference programme

8:30 Registration & Coffee

9:00 Chairman's Opening Remarks

Howard Stevens

Howard Stevens, Assistant Head of Institute and Professor of Drug Delivery, University of Strathclyde

9:10 Lipid suspensions - how, when and with what?

Rene Holm

Rene Holm, Head and Scientific Director, Liquids & Parenterals, Janssen

• What is a lipid based suspension and how could it look from a commercialisation perspective?
• When can lipid based suspensions be used to improve the oral bioavailability?
• How large a proportion of the compound needs to be solubilised in the lipid phase?
• What excipients to use for lipid based formulation?
 

9:50 Novel injectable formulations for postoperative pain with opioid sparing

Damon Smith

Damon Smith, CEO, Polymeric Particles & Altus Formulation

• NSAID analgesics administered concomitantly can greatly decrease opioid doses for effective analgesia (so-called opioid sparing) but in many cases they are poorly delivered.
• We are using our proprietary SmartCelle technology to develop a range of low volume, high concentration injectable NSAID and COX-II  products for the treatment of postoperative pain.
• Unlike today’s treatments which are quickly cleared from the body, the pharmacokinetics imparted by SmartCelle can maintain blood concentration of drug sufficiently to double exposure versus non-formulated drug.
 

10:30 Morning Coffee

11:00 Controlled erosion facilitates development of complex oral delivery profiles

Howard Stevens

Howard Stevens, Assistant Head of Institute and Professor of Drug Delivery, University of Strathclyde

• Therapeutic opportunities for Complex Oral Delivery Profiles?
• How to harness in-vivo erosion to achieve CODPs?
• In-vivo Evaluation of CODPs?
 

11:40 From ideas to novel drug products - parenteral and oral controlled release drug delivery strategies

Hans Baer

Hans Baer, Senior project manager, Evonik Nutrition & Care GmbH

• Controlled release formulation design, scale-up and GMP manufacturing of PLGA-based microparticles
• Multi-unit oral dosage form with EUDRATEC® PEP  for oral delivery of macromolecules and poorly permeable small drugs.
• Evonik platform technologies offer a combination of synergistic modules for improved bioavailability in combination with a tailored drug release profile
 

12:20 Networking Lunch

13:50 Parenteral delivery of nano-carriers

Jim Jingjun  Huang

Jim Jingjun Huang, Founder and CEO, Ascendia Pharmaceuticals LLC

• Hurdles in the design of parenteral drug delivery systems for insoluble compounds
• Summary of solubilization and parenteral delivery technologies
• The key considerations in design of parenteral drug delivery system
• Case studies in development of nanocarriers
 

14:30 Delivery and release of small molecules and biologics using Nanocin technology

Liam Good

Liam Good, Director, Tecrea Ltd

• Nanocin™ forms nanoparticles on interaction with nucleic acids, proteins, peptides and small molecules
• The polymer has a low toxicity profile and a long history of safe use
• Nanocin™:drug particles and examples of cell entry and functional effects will be presented
 

15:10 Afternoon Tea

15:40 The nanomedicine experience

Ijeoma Uchegbu

Ijeoma Uchegbu, Scientific Secretary CRS, Chair in Pharmaceutical Nanoscience, University Of London

• The talk will explore the design and synthesis of nanomedicine forming materials
• Their fabrication into differentiated nanomedicines.
• Case studies will include data on peptide brain delivery
 

16:20 Examining how Quality by Design (QbD) can aid formulation and controlled release delivery

David Elder

David Elder, Constultant, David P Elder Consultancy

• Assessing the importance of QbD in controlled release delivery
• Implementation of QbD principles in the development of microsponges as drug delivery carriers
• The advantages of implementing QbD into controlled release systems
 

17:00 Biodegradable polymeric microparticles and hydrogels for parenteral drug delivery

Martin Bakker

Martin Bakker, Chief Business Development Officer, Innocore Pharmaceuticals

- Whereas PLGA has its limitations for protein delivery causing e.g. burst, pH drop and instability, a different biodegradable polymer platform will be shared to solve the issues
* Demonstrating excellent control over release kinetics and effective preservation of protein bioactivity
* Several case studies will be presented to exhibit all requirements to develop sustained release formulations for parenteral delivery of biologic therapeutics.
 

17:40 Chairman’s Closing Remarks and Close of Day One

Howard Stevens

Howard Stevens, Assistant Head of Institute and Professor of Drug Delivery, University of Strathclyde

8:30 Registration & Coffee

9:00 Chairman's Opening Remarks

Sudhakar Garad

Sudhakar Garad, Global Head of Chemical and Pharmaceutical Profiling, Novartis Institutes for BioMedical Research Inc

9:10 Generic drug development and evaluation: A U.S. FDA perspective

Markham Luke

Markham Luke, Director, Division of Therapeutic Performance, FDA

• Bioequivalence in the setting of pharmaceuticals
• Definitions – what are complex drug products
• How FDA assists generic drug development
 

9:50 The development and commercialisation of drug delivery systems: Challenges and opportunities

Mark Wilson

Mark Wilson, Director, Collaboration Management, Pharmaceutical Development Division, GlaxoSmithKline plc

• GSK’s experiences in developing technologies
• The collaborative “open innovation” approach
• Commercialisation challenges – finding the breakthrough application
• Examples of successful development and exploitation projects
• GSK’s approach to working with other organisations

 

10:30 Morning Coffee

11:00 NEUWAY Pharma: Qualified for CNS drug delivery

Heiko Manninga

Heiko Manninga, Managing Director, Co-Founder, NEUWAY Pharma GmbH

• Treatment of CNS diseases is not limited by drugs, but by delivery.
• The majority of active substances is excluded from the CNS by the blood-brain-barrier
• NEUWAY is focusing on providing a gateway for drugs via this natural border
• NEUWAY’s engineered protein capsules (EPCs) consist of the natural VP1 protein of JV Virus - a virus that knows how to overcome the blood-brain barrier.
• EPCs are non-infectious and can be filled with a variety of therapeutic molecules
 

11:40 Matrix-binding fusions for local delivery of therapeutics

Parth Patwari

Parth Patwari, Founder & CSO, ProteoThera


--Challenges in delivery to tissues with dense matrix and poor vasculature
--Nature-inspired solutions using binding to matrix components
--Matrix-binding fusions for intra-articular delivery with extended retention


 

12:20 Networking Lunch

13:50 Biopharmaceutical approaches for controlled release delivery

Sudhakar Garad

Sudhakar Garad, Global Head of Chemical and Pharmaceutical Profiling, Novartis Institutes for BioMedical Research Inc

• Why controlled drug delivery – pros and cons
• Past, today and future for controlled delivery
• What biopharmaceutical properties needs to be considered for designing a controlled release dosage form
• Pharmaceutical consideration for oral, topical or parenteral controlled delivery
• Patient preference and commercial impact 
 

14:30 Improving solubility and bioavailabilty

Stephan Buchmann

Stephan Buchmann, Head Preformulation and Preclinical Galenics, Actelion Ltd.

• Basic principles to be considered
• Opportunities and limitations to improve solubility and bioavailability
• Presentation of case studies
 

15:10 Afternoon Tea

15:40 Hydrogel formulations for biologics

Patrick Garidel

Patrick Garidel, Department of Process Science, Formulation Development, Boehringer-Ingelheim

• Rational for sustained release formulations for biologics
• Influence of gel network properties on release kinetics
• Impact of molecular format on release kinetics
• Drug-delivery system compatibility
• Case studies
 

16:20 Utilizing novel technology to accelerate drug development

John Fox

John Fox, Chief Development Officer, Merrion Pharmaceuticals

• Apply new technology to accelerate drug development pipeline and develop novel formulations
• Delivering benefit to the patient while creating novel formulations
• Translating the technology from use in R&D to clinical output
 

17:00 Chairman’s Closing Remarks and Close of Day Two

Sudhakar Garad

Sudhakar Garad, Global Head of Chemical and Pharmaceutical Profiling, Novartis Institutes for BioMedical Research Inc

+

FEATURED SPEAKERS

Mark Wilson

Mark Wilson

Director, Collaboration Management, Pharmaceutical Development Division, GlaxoSmithKline plc
Markham Luke

Markham Luke

Director, Division of Therapeutic Performance, FDA
Rene Holm

Rene Holm

Head and Scientific Director, Liquids & Parenterals, Janssen
Stephan Buchmann

Stephan Buchmann

Head Preformulation and Preclinical Galenics, Actelion Ltd.
Sudhakar Garad

Sudhakar Garad

Global Head of Chemical and Pharmaceutical Profiling, Novartis Institutes for BioMedical Research Inc

Damon Smith

CEO, Polymeric Particles & Altus Formulation
Damon Smith

David Elder

Constultant, David P Elder Consultancy
David Elder

Hans Baer

Senior project manager, Evonik Nutrition & Care GmbH
Hans Baer

Heiko Manninga

Managing Director, Co-Founder, NEUWAY Pharma GmbH
Heiko Manninga

Howard Stevens

Assistant Head of Institute and Professor of Drug Delivery, University of Strathclyde
Howard Stevens

Ijeoma Uchegbu

Scientific Secretary CRS, Chair in Pharmaceutical Nanoscience, University Of London
Ijeoma Uchegbu

Jim Jingjun Huang

Founder and CEO, Ascendia Pharmaceuticals LLC
Jim Jingjun  Huang

John Fox

Chief Development Officer, Merrion Pharmaceuticals
John Fox

Liam Good

Director, Tecrea Ltd
Liam Good

Mark Wilson

Director, Collaboration Management, Pharmaceutical Development Division, GlaxoSmithKline plc
Mark Wilson

Markham Luke

Director, Division of Therapeutic Performance, FDA
Markham Luke

Martin Bakker

Chief Business Development Officer, Innocore Pharmaceuticals
Martin Bakker

Parth Patwari

Founder & CSO, ProteoThera
Parth Patwari

Patrick Garidel

Department of Process Science, Formulation Development, Boehringer-Ingelheim
Patrick Garidel

Rene Holm

Head and Scientific Director, Liquids & Parenterals, Janssen
Rene Holm

Stephan Buchmann

Head Preformulation and Preclinical Galenics, Actelion Ltd.
Stephan Buchmann

Sudhakar Garad

Global Head of Chemical and Pharmaceutical Profiling, Novartis Institutes for BioMedical Research Inc
Sudhakar Garad

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Challenges in inhaled drug delivery
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Challenges in inhaled drug delivery

Copthorne Tara Hotel
5th April 2017
London, United Kingdom

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Copthorne Tara Hotel

Scarsdale Place, Kensington, London, United Kingdom

The Copthorne Tara Hotel London Kensington is an elegant contemporary four-star hotel in prestigious Kensington, located just a two minutes walk from High Street Kensington underground station, making exploring easy. The hotel offers well-appointed and comfortable guest rooms combining Standard, Superior and Club accommodation. Club rooms offer iconic views over the city and include Club Lounge access for complimentary breakfast and refreshments. Guests can sample the authentic Singaporean, Malaysian and Chinese cuisine at Bugis Street, traditional pub fare at the Brasserie Restaurant & Bar or relax with a delicious drink at West8 Cocktail Lounge & Bar.

The Copthorne Tara Hotel boasts 745 square meters of flexible meeting space, consisting of the Shannon Suite and the Liffey Suite, ideal for hosting conferences, weddings and social events. Facilities include access to the business centre 24 hours a day, fully equipped fitness room, gift shop, theatre desk and Bureau de Change. With ample onsite parking outside the London congestion charge zone and excellent transport links via Heathrow Airport, the hotel is the perfect location for business or leisure stays. The hotel is within close proximity to the shops of High Street Kensington, Knightsbridge and Westfield London, Olympia Conference Centre, Royal Albert Hall, Kensington Palace and Hyde Park.

 

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Copthorne Tara Hotel

Scarsdale Place
Kensington
London W8 5SR
United Kingdom

Copthorne Tara Hotel

The Copthorne Tara Hotel London Kensington is an elegant contemporary four-star hotel in prestigious Kensington, located just a two minutes walk from High Street Kensington underground station, making exploring easy. The hotel offers well-appointed and comfortable guest rooms combining Standard, Superior and Club accommodation. Club rooms offer iconic views over the city and include Club Lounge access for complimentary breakfast and refreshments. Guests can sample the authentic Singaporean, Malaysian and Chinese cuisine at Bugis Street, traditional pub fare at the Brasserie Restaurant & Bar or relax with a delicious drink at West8 Cocktail Lounge & Bar.

The Copthorne Tara Hotel boasts 745 square meters of flexible meeting space, consisting of the Shannon Suite and the Liffey Suite, ideal for hosting conferences, weddings and social events. Facilities include access to the business centre 24 hours a day, fully equipped fitness room, gift shop, theatre desk and Bureau de Change. With ample onsite parking outside the London congestion charge zone and excellent transport links via Heathrow Airport, the hotel is the perfect location for business or leisure stays. The hotel is within close proximity to the shops of High Street Kensington, Knightsbridge and Westfield London, Olympia Conference Centre, Royal Albert Hall, Kensington Palace and Hyde Park.

 

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WHAT IS CPD?

CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.

CPD AND PROFESSIONAL INSTITUTES

There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.

TYPICAL CPD SCHEMES AND RECORDING OF CPD (CPD points and hours)

Professional bodies and Institutes CPD schemes are either structured as ‘Input’ or ‘Output’ based.

‘Input’ based schemes list a precise number of CPD hours that individuals must achieve within a given time period. These schemes can also use different ‘currencies’ such as points, merits, units or credits, where an individual must accumulate the number required. These currencies are usually based on time i.e. 1 CPD point = 1 hour of learning.

‘Output’ based schemes are learner centred. They require individuals to set learning goals that align to professional competencies, or personal development objectives. These schemes also list different ways to achieve the learning goals e.g. training courses, seminars or e:learning, which enables an individual to complete their CPD through their preferred mode of learning.

The majority of Input and Output based schemes actively encourage individuals to seek appropriate CPD activities independently.

As a formal provider of CPD certified activities, SMI Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.

GLOBAL CPD

Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

CPD Certificates

We can provide a certificate for all our accredited events. To request a CPD certificate for a conference , workshop, master classes you have attended please email events@smi-online.co.uk

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