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SMi Group is thrilled to announce the 20th Annual Superbugs & Superdrugs Conference in London on 19th – 20th March 2018. As the global threat of antimicrobial resistance continues to develop, it is clear that a global commitment is required in order to tackle the ever-increasing problem of multidrug-resistant bacteria.

This year’s event will gather leaders from pharmaceutical companies, academia and the wider scientific community together with regulatory agencies and public-private partnerships, to discuss the growing threat of antibiotic resistance. Join us to learn about various strategies in place to support antimicrobial resistance research & development, evaluate the latest scientific advancements for tackling antimicrobial resistance and consider potential novel candidates and alternatives to anti-microbials. The event will also focus on the strategies pharmaceutical companies use to assist the development of new therapeutics & drugs, how to obtain funding for new projects and address why there is a current lack of incentives for researchers working in antimicrobial resistance research and development.

 

• Analyze the current status of the situation and insight into the strategies to tackle antimicrobial resistance by industry experts
• Hear from Pharmaceutical Companies about the Practical Implementations they are utilizing in order to tackle AMR
• Learn about the regulatory pathways for the registration of new antimicrobial agents and how changes might affect antimicrobial resistance research & development
• Discuss the role the pharmaceutical industry should play in tackling antimicrobial resistance and how to tackle the lack of incentives for researchers working in this industry
• Explore new approaches and strategies being used by industry professionals and scientific pioneers to develop new antibiotics for multi-drug resistant bacteria
• Evaluate the latest novel alternatives to antibiotics currently in development
 

Previous attendees include:

7i Med Ltd; ACT Surfaces ; Alacrita LLP; Anti-infectives ; Antikor Biopharma; Arsanis Biosciences GmbH; Auspherix Ltd; BARDA; BIOASTER; Blueberry Therapeutics Ltd. ; Cantab Anti-infectives; Cempra Pharmaceuticals; Centauri Therapeutics; Chemical Biology Ventures; Clarivate Analytics; Da Volterra; Drugs for Neglected Diseases initiative (DNDi); dstl (Defence Science and Technology Laboratory); Elsevier; Emergent BioSolutions; Emergent BioSolutions Inc.; European Commision; Evotec; F. Hoffmann-La Roche; F. Hoffmann-La Roche Ltd.; Fidelta Ltd; GOETZPARTNERS CORPORATE FINANCE LIMITED; Karolinska Institute; KWS BioTest; Laboratoire Biodim; Medecins Sans Frontieres; MGB Biopharma; MHRA; Mutabilis S A; Neem Biotech; Nemesis bioscience ; NeoSome Life Sciences, LLC; Northern Antibiotics Ltd.; Nosopharm; Office of Health Economics (OHE); Phico Therapeutics; Phico Therapeutics Ltd; Polyphor Ltd; QuantumDX; Sankio Pharma Gmbh; Spero Therapeutics; St George's, University of London; The Wellcome Trust; Tiber Creek Partners; TNO Pharma; TranScrip Partners; TranScrip Partners LLP; University Hospital of Copenhagen ; University Of Liverpool; University of North Texas Health Science Center; Venaticus Symcel ; VIB; Wellcome Trust;

Conference programme

8:30 Registration & Coffee

9:00 Chairman's Opening Remarks

Richard Bax

Richard Bax, Senior Partner, TranScrip Partners
View Bio

9:15 Tackling the current lack of incentives for people working in antimicrobial research and development

9:55 GARDP- facilitating R&D for new antibiotic treatments

Jean-Pierre Paccaud

Jean-Pierre Paccaud, Director of Business Development at GARDP, Drugs for Neglected Diseases initiative (DNDi)
View Bio

10:35 Morning Coffee

11:05 Bacterial cybergenetics to resurrect sensitivity to antibiotics in anti-microbial resistant (AMR) pathogens

Conrad Lichtenstein

Conrad Lichtenstein, CSO, Nemesis bioscience
View Bio

• “Nemesis Symbiotics” use programmable RNA-guided DNA endonuclease gene editing technology to target antibiotic resistance genes.
• A single Symbiotic inactivates members of multiple families of resistance genes –so resurrecting sensitivity to antibiotics.
• Pre-clinical studies show that Transmids, our novel vectors, deliver Symbiotics to bacteria by phage-coat infection and subsequently spread by bacterial conjugation.
• Symbiotics are biological companion therapeutics to be used together with well-established antibiotics for both therapeutic treatment of infection as well as prophylactic treatment preventing the spread of AMR.

11:45 Using immune modulation alongside antibiotics to counter multidrug-resistant bacteria

David Brown

David Brown, Managing Director and Founder, Alchemy Biomedical Consulting
View Bio

• The antibiotic field can arguably learn from oncology where immune modulation used alongside chemotherapy has transformed treatment prospects.
• Similarly, to beat resistant bacteria, we need to counter the way they usurp our immune defenses to evade antibiotics.
• Summarising novel ideas on using immune modulation alongside antibiotics to beat resistant species.
• Suggesting that adding a third component could reduce death rates from sepsis which remain very high even with use of modern antibiotics.

12:25 Networking Lunch

13:35 Use of the PasNas platform to enable high quality antibacterial hit finding

Domingo  Gargallo-Viola

Domingo Gargallo-Viola, Chief Scientific Officer, ABAC Therapeutics
View Bio

• The infectious diseases drug discovery is enormously inefficient. We can not repeat things over and over again. What can we do to change this trend?
• Disruptive Innovation to control risk factors, improve efficiency and ensure delivery. 
• New paradigms in infectious diseases, from magic bullet to precision antibacterial agents
 

14:15 Building a detailed computational network model of cell envelope biogenesis: a systems biology approach to developing antibacterial drugs (potentiators)

John George

John George, CSO, Oppilotech
View Bio

• Model incorporates the synthesis of key components including LPS, phospholids and peptidoglycan
• The model is used to guide the identification of potentiator targets– agents that can enhance the activities of existing antibiotics
• Potentiator programmes derived from model
 

14:55 Afternoon Tea

15:25 Teaching old cephalosporin dogs new mechanistic tricks against MDR Gram-negative bacteria

Larry Sutton

Larry Sutton, Scientific Founder, Gladius Pharmaceuticals
View Bio

• Cephalosporin synthetic scaffolding for new mechanisms
 In vitro activity versus WHO critical priority pathogens
• Comparison to new combination β-lactams
• In vivo performance

16:05 SPARKing New Antibiotic Discovery – the Shared Platform for Antibiotic Research and Knowledge

Kathy Talkington

Kathy Talkington, Project Director, Pew charitable trusts
View Bio

• The Shared Platform for Antibiotic Research and Knowledge is a groundbreaking and dynamic information-sharing platform.
• Bringing together curated antibiotic discovery data and cutting-edge analytics to help scientists tackle the scientific barriers blocking antibiotic discovery.
• While the global threat of antibiotic resistance continues to rise, nearly every antibiotic in use today is based on a discovery from more than 30 years ago.
• SPARK will focus on the unique challenges of finding and designing antibiotics that can defeat drug-resistant Gram-negative bacteria, which are among the hardest-to-treat superbugs
 

16:45 Chairman’s Closing Remarks and Close of Day One

Richard Bax

Richard Bax, Senior Partner, TranScrip Partners
View Bio

8:30 Registration & Coffee

9:00 Chairman's Opening Remarks

Lloyd Czaplewski

Lloyd Czaplewski, Director, Chemical Biology Ventures
View Bio

9:10 Highlights from the Traditional and Alternative Antibacterial Pipeline

Lloyd Czaplewski

Lloyd Czaplewski, Director, Chemical Biology Ventures
View Bio

• What new therapies can we anticipate?
• Research challenges
• Are we asking the right questions?

9:50 Regulatory considerations for the registration of new antibacterial agents

Mair Powell

Mair Powell, Senior clinical assessor, MHRA
View Bio

• Ensuring that candidate antibacterial agents with potential to address an unmet need are evaluated in line with regulatory guidance
• Options for clinical development programmes
• Importance of the pharmacokinetic-pharmacodynamic relationship 
• Update on recent guidance and planned revisions to EMA guidance

10:30 Morning Coffee

11:00 Iclaprim: a well differentiated, targeted, potent and rapidly bactericidal antibiotic against multidrug resistant bacteria

David Huang

David Huang, Chief Medical Officer, Motif BioSciences
View Bio

• Exploring a novel mechanism of action different from any other antibiotic currently in development
• Positive clinical outcomes among patients with ABSSSI and HAP/VAP through optimizing iclaprim's dose and the concentration at sites of infection
• Looking into safety data and what lies ahead to achieve FDA and EMA approval

11:40 Opening up new opportunities for the treatment of infectious diseases using nanoformulations

David Cook

David Cook, Chief Scientific Officer , Blueberry Therapeutics Ltd.
View Bio

• Nanoformulations formulate drugs into nanoparticles and can greatly enhance their pharmacokinetic and pharmacodynamics properties
• Exploring the potential of novel drug nanoformulations to create new treatments for infections
• Presentation of research and discussion of the potential of nanoformulations more broadly in infectious disease

12:20 Networking Lunch

13:20 Challenges in Antimicrobial Evaluation of Novel Therapies using Animal Models

William Weiss

William Weiss, Director of Pre-Clinical Services, University of North Texas Health Science Center
View Bio

• Where to start / What model to use
• Dose / Regimen – How to choose
• Test articles with no intrinsic activity
• How to evaluate combination therapy
• What does the data tell us?
 

14:00 Lysins: Alternative Antimicrobials to Improve Clinical Outcomes Serious Bacterial Infections - CF-301 - A Case Study

Cara Cassino

Cara Cassino, Chief Medical Officer, ContraFect
View Bio

• CF-301 demonstrates the hallmark features of lysins, including: rapid, targeted bacteriolysis, potent synergy with conventional antibiotics, activity against antibiotic-resistant strains, low propensity for resistance and remarkable biofilm eradication, which make lysins attractive therapeutic candidates for serious bacterial infections.
• In vivo studies with CF-301 signal the therapeutic potential of lysins boost the efficacy of conventional antibiotics and combat antimicrobial resistance 
• The ongoing CF-301 clinical development program will help define the place in therapy for ability of lysin therapeutics in the treatment of serious, invasive, biofilm-dependent bacterial infections is being evaluated in clinical development
 

14:40 Afternoon Tea

15:10 C. auris – a difficult to treat, emerging pathogen

Stephen Barat

Stephen Barat, Head of Pre-Clinical and Early Clinical Development, SCYNEXIS Inc

• Brief history of C. auris
• How C. auris differs from other candida species
• Experimental models of C. auris
• New potential treatments

15:50 Amelioration of multi drug resistant infection by antibody modulation

Ian Henderson

Ian Henderson , Professor of Microbial Biology, University Of Birmingham

• Some individuals overproduce antibody that recognises surface structures on bacteria
• Such antibody interferes with serum killing of the bacterium
• Removal of these antibodies by apharesis restores serum killing
• Restoration  of serum killing is associated with clinical improvement

16:30 Chairman’s Closing Remarks and Close of Day Two

Lloyd Czaplewski

Lloyd Czaplewski, Director, Chemical Biology Ventures
View Bio

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Workshops

The Use of Animal Models in Pre-clinical Drug Development
Workshop

The Use of Animal Models in Pre-clinical Drug Development

Copthorne Tara Hotel
21st March 2018
London, United Kingdom

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Copthorne Tara Hotel

Scarsdale Place, Kensington, London, United Kingdom

The Copthorne Tara Hotel London Kensington is an elegant contemporary four-star hotel in prestigious Kensington, located just a two minutes walk from High Street Kensington underground station, making exploring easy. The hotel offers well-appointed and comfortable guest rooms combining Standard, Superior and Club accommodation. Club rooms offer iconic views over the city and include Club Lounge access for complimentary breakfast and refreshments. Guests can sample the authentic Singaporean, Malaysian and Chinese cuisine at Bugis Street, traditional pub fare at the Brasserie Restaurant & Bar or relax with a delicious drink at West8 Cocktail Lounge & Bar.

The Copthorne Tara Hotel boasts 745 square meters of flexible meeting space, consisting of the Shannon Suite and the Liffey Suite, ideal for hosting conferences, weddings and social events. Facilities include access to the business centre 24 hours a day, fully equipped fitness room, gift shop, theatre desk and Bureau de Change. With ample onsite parking outside the London congestion charge zone and excellent transport links via Heathrow Airport, the hotel is the perfect location for business or leisure stays. The hotel is within close proximity to the shops of High Street Kensington, Knightsbridge and Westfield London, Olympia Conference Centre, Royal Albert Hall, Kensington Palace and Hyde Park.

 

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Copthorne Tara Hotel

Scarsdale Place
Kensington
London W8 5SR
United Kingdom

Copthorne Tara Hotel

The Copthorne Tara Hotel London Kensington is an elegant contemporary four-star hotel in prestigious Kensington, located just a two minutes walk from High Street Kensington underground station, making exploring easy. The hotel offers well-appointed and comfortable guest rooms combining Standard, Superior and Club accommodation. Club rooms offer iconic views over the city and include Club Lounge access for complimentary breakfast and refreshments. Guests can sample the authentic Singaporean, Malaysian and Chinese cuisine at Bugis Street, traditional pub fare at the Brasserie Restaurant & Bar or relax with a delicious drink at West8 Cocktail Lounge & Bar.

The Copthorne Tara Hotel boasts 745 square meters of flexible meeting space, consisting of the Shannon Suite and the Liffey Suite, ideal for hosting conferences, weddings and social events. Facilities include access to the business centre 24 hours a day, fully equipped fitness room, gift shop, theatre desk and Bureau de Change. With ample onsite parking outside the London congestion charge zone and excellent transport links via Heathrow Airport, the hotel is the perfect location for business or leisure stays. The hotel is within close proximity to the shops of High Street Kensington, Knightsbridge and Westfield London, Olympia Conference Centre, Royal Albert Hall, Kensington Palace and Hyde Park.

 

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WHAT IS CPD?

CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.

CPD AND PROFESSIONAL INSTITUTES

There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.

TYPICAL CPD SCHEMES AND RECORDING OF CPD (CPD points and hours)

Professional bodies and Institutes CPD schemes are either structured as ‘Input’ or ‘Output’ based.

‘Input’ based schemes list a precise number of CPD hours that individuals must achieve within a given time period. These schemes can also use different ‘currencies’ such as points, merits, units or credits, where an individual must accumulate the number required. These currencies are usually based on time i.e. 1 CPD point = 1 hour of learning.

‘Output’ based schemes are learner centred. They require individuals to set learning goals that align to professional competencies, or personal development objectives. These schemes also list different ways to achieve the learning goals e.g. training courses, seminars or e:learning, which enables an individual to complete their CPD through their preferred mode of learning.

The majority of Input and Output based schemes actively encourage individuals to seek appropriate CPD activities independently.

As a formal provider of CPD certified activities, SMI Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.

GLOBAL CPD

Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

CPD Certificates

We can provide a certificate for all our accredited events. To request a CPD certificate for a conference , workshop, master classes you have attended please email events@smi-online.co.uk

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