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Superbugs & Superdrugs 2019
18 March - 19 March 2019
Superbugs & Superdrugs 2019


This year’s event will gather leaders from pharmaceutical companies, academia and the wider scientific community together with regulatory agencies and public-private partnerships, to discuss the growing threat of antibiotic resistance.

Join us to learn about various strategies in place to support antimicrobial resistance research & development, evaluate the latest scientific advancements for tackling antimicrobial resistance and consider potential novel candidates and alternatives to anti-microbials.

The event will also focus on the strategies pharmaceutical companies use to assist the development of new therapeutics & drugs, how to obtain funding for new projects and address why there is a current lack of incentives for researchers working in antimicrobial resistance research and development.
 


 

FEATURED SPEAKERS

Chandrabali Ghose

Chandrabali Ghose

CEO, Bioharmony Therapeutics
Chris Pickford

Chris Pickford

Head of Drug Discovery, Centauri Therapeutics
Christopher Schofield

Christopher Schofield

Head of Organic Chemistry, Oxford University
David Cook

David Cook

Chief Scientific Officer, Blueberry Therapeutics Ltd
David Roblin

David Roblin

President of R&D, Chief Operating Officer and Chief Medical Officer, Summit Theraputics
John  Rex

John Rex

Chief Medical Officer , F2G Ltd
Kazunori Maebashi

Kazunori Maebashi

Senior Project Manager, Meiji Seika Pharma Co. Ltd.
Lloyd Czaplewski

Lloyd Czaplewski

Director, Chemical Biology Ventures
Richard Bax

Richard Bax

Senior Partner, TranScrip Partners
William  Hope

William Hope

Professor of Therapeutics and Infectious Diseases, University Of Liverpool

Anthony Coates

Chief Scientific Officer, St George's, University of London
Anthony Coates

Professor Anthony Coates founded Helperby Therapeutics in 2002.

With his colleague Dr Yanmin Hu he invented and patented a new way of discovering combinations of antibiotics which kill highly resistant bacteria. The Company is now in clinical trials with potential new combination treatments for multi-drug resistant bacterial infections.

Sir Anthony is the Professor of Medical Microbiology at St George’s, University of London, leads research teams, is author of over 150 publications, and is recipient of national & international grants from the European Commission and industry.
 

Carley Smith

Practitioner, Fairy Gut Mother
Carley Smith

Carley Smith, AKA Fairy Gutmother®, is a Nutritional Therapist, Certified GAPS Practitioner, and Registered Yoga Teacher. Carley became interested in health and nutrition after being diagnosed with Lyme disease and using food as medicine emphasizing gut health to help heal. She became so empowered in the progress in her healing just based on diet and lifestyle changes emphasizing gut health that she started Fairy Gutmother® so she could help spread awareness around nutrition and help others. Carley is adamant about promoting the gut health lifestyle as it is more than a diet, rather, a combination of food and environment that play a role in the health of the microbiome. Carley has been a featured guest on The Dr. Oz Show and is a frequent guest and writer for the popular iHeart Radio show Modern Eater. Her articles have been published in major worldwide publications including MindBodyGreen, Yoga + Life Magazine, N by Norwegian Magazine, and Paleo Magazine to name a few. She leads numerous workshops and public speaking events centered around the gut health lifestyle, most recently presenting at an Ignite® talk, a prominent worldwide public speaking event.

Chandrabali Ghose

CEO, Bioharmony Therapeutics
Chandrabali Ghose

Chandrabali Ghose is the founder and CEO of Bioharmony Therapeutics, an early-stage biotech startup specializing in the development of novel antimicrobials to combat drug-resistant bacterial infections. Chandra spent 8 years at the Aaron Diamond AIDS Research Center, an affiliate of Rockefeller University. Prior to that, Chandra was a postdoctoral fellow at Harvard Medical School. Chandra earned her PhD from New York University School of Medicine and her bachelor’s degree from Saint Louis University. She has published high-impact peer-reviewed articles and book chapters in the field of infectious diseases and has received many awards for her scientific and entrepreneurial contributions.

Chris Pickford

Head of Drug Discovery, Centauri Therapeutics
Chris Pickford

Chris is currently the Head of Drug Discovery at Centauri Therapeutics. He leads the scientific team to deliver drug candidates into the clinic, responsible for the pre-clinical labs at Discovery Park, Sandwich, UK. Before joining Centauri Therapeutics, Chris was a Research Director at Agalimmune, an immuno-oncology biotech and a project leader for Salvensis, a neglected diseases drug discovery company. In addition, Chris worked for 12 years as part of Pfizer’s Research and Development organization, leading infectious diseases projects from new target identification to first-in-human trials. Chris studied for a biochemistry degree at the University of Birmingham and obtained a PhD from the National Institute of Medical Research, London

Christopher Schofield

Head of Organic Chemistry, Oxford University
Christopher Schofield

Chris Schofield studied for a degree in chemistry at the University of Manchester (1979-1982). In 1982 he moved to Oxford for DPhil studies with Jack Baldwin on the synthesis and biosynthesis of antibiotics. In 1985 he became a Departmental Demonstrator in the Dyson Perrins Laboratory, and in 1990 Lecturer in Chemistry and Fellow of Hertford College. In 1998 he became Professor of Chemistry, and in 2011 was appointed Head of Organic Chemistry. He is a Fellow of the Royal Society.

His research group works at the interface of chemistry, biology and medicine. His work has opened up new fields in antibiotic research, oxygen sensing and gene regulation in organisms ranging from bacteria to plants and animals. His work has identified new opportunities for medicinal intervention that are being pursued by numerous academic and commercial laboratories.
 

David Cook

Chief Scientific Officer, Blueberry Therapeutics Ltd
David Cook

David has a background in biochemistry, immunology and molecular biology with a PhD from Imperial College, London and three years of post-doctoral experience. David has worked in the pharmaceutical industry for almost 20 years. He worked in big pharma at AstraZeneca for more than 17 years in a wide variety of R&D roles both in the UK and the US. Whilst at AstraZeneca he was heavily involved in developing the use of informatics and systems biology to support the development of new medicines. David joined Blueberry Therapeutics as Chief Scientific Officer at the start of 2014. In this role, he is responsible for leading the research activities of the business which are focused on developing new treatments for common dermatological diseases. The first of these treatments is now in clinical testing.

David Roblin

President of R&D, Chief Operating Officer and Chief Medical Officer, Summit Theraputics
David Roblin

David is an experienced scientist and physician, with a distinguished career in the pharmaceutical industry. He and his units have brought many medicines in several therapy areas through R&D to successful commercialisation; including in anti-infectives azithromycin, ciprofloxacin, moxifloxacin, voriconazole and selzentry.
He is currently President of R&D at Summit Therapeutics plc, an international clinical-stage company listed on AIM and NASDAQ developing new mechanism antibiotics. David is also a non-executive director of Sosei PLC and sits on a variety of committees at Wellcome, on the UK Biomedical Catalyst Fund and the LEO Foundation prize committee.
He has previously served as the Chief Operating Officer and Director of Scientific Translation at the Francis Crick Institute in London (2014 – 2017). Prior to this, he was Head of Research and Chief Medical Officer for Europe R&D at Pfizer Inc. from 2008 to 2011 and was Head of Therapy Area for Anti-infectives at Bayer AG from 1997 to 1999.
David has a degree in biochemistry from University of London and qualified in Medicine from St George’s Hospital, London. He is a Fellow of the Royal College of Physicians, Fellow of the Faculty of Pharmaceutical Medicine and a Fellow of the Academy of Medical Sciences. He is an honorary Professor of Medicine at Swansea University and Professor of Translational Medicine at St George’s.

Eirikur Steingrimsson

Co-founder, Akthelia Pharmaceuticals
Eirikur Steingrimsson

Eirikur Steingrimsson is a founder of Akthelia and professor of Molecular Biology in the Faculty of Medicine at the University of Iceland and is an expert in gene regulation. He has over 20 years of experience in this area and has published his work in leading international journals. He is an EMBO member. During the years 2003-2005 he served as the CSO of Iceland Genomics Corporation, now a component of Decode Genetics.

Fiona Rudkin

Principal Investigator/CEO, MycoBiologics at University of Aberdeen
Fiona Rudkin

Fiona Rudkin obtained her PhD in microbiology from the University of Aberdeen in 2015. Prior to this, Fiona worked in the Global Biotherapeutics Division at Pfizer on early-stage drug discovery programmes. Her PhD and subsequent work as a Research Fellow in the Medical Research Council Centre for Medical Mycology at the University of Aberdeen was focused on generating and validating human antibodies as potential new diagnostics and therapeutics for the major human fungal pathogen Candida. In 2017, Dr. Rudkin was awarded a Royal Society of Edinburgh Enterprise Fellowship to commercialize this research and create mycoBiologics. This pre-commercialisation vehicle is focused on the targeted treatment of life-threatening multi-drug resistant (MDR) fungal pathogens.

Heather Fairhead

CEO, Phico Therapeutics
Heather Fairhead

Dr Heather Fairhead, CEO, founded Phico Therapeutics in 2000 to develop a unique first-in-class antibacterial technology, SASPject. Heather has raised >£25 M to date from private investment, Wellcome Trust and UK Government grants and has led the company through its first clinical trial in humans. Prior to her scientific career, Heather gained several years’ commercial experience working in marketing/sales across a range of industries. Heather has a 1st class honours degree in biotechnology from Nottingham University and a PhD in Molecular Microbiology from Sheffield University and has research experience from both Cambridge and Connecticut Universities.

James Anderson

European Partnerships Director, GSK
James Anderson

In his role as Head of Corporate Government Affairs, James leads engagement with the UK Government to deliver GSK’s strategic agenda, spanning R&D, Manufacturing, Commercial and Corporate aspects of GSK’s three businesses: pharmaceuticals, vaccines, consumer. He seeks creative opportunities to partner with the Government and to mitigate risks. James is a member of the Life Science Strategy Board.

James also leads global GSK advocacy on Antimicrobial Resistance (AMR). He has advised policy development on AMR at the WHO, UN, EU Commission, the O’Neill Review and National Governments. He is Vice Chair of the Industry IFPMA AMR Committee, a Board member of the AMR Alliance and regularly speaks on behalf of industry, building on his role in developing the Davos Declaration and 2016 UNGA Industry AMR Roadmap. In the UK, James Chairs the ABPI AMR network and the Government-Industry AMR taskforce
 

John Rex

Chief Medical Officer , F2G Ltd
John  Rex

Kazunori Maebashi

Senior Project Manager, Meiji Seika Pharma Co. Ltd.
Kazunori Maebashi

Dr. Kazunori Maebashi has been a Senior Project Manager at Meiji Seika Pharma Co., Ltd., Japan since 2011. He became a researcher at Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd. in 2000. During 1986-2000, he worked for Central Research Laboratories at SSP Co., Ltd., Japan. His experiences range from drug discovery to clinical phases of antibacterial and antifungal agents. He contributed to research and development of drugs such as tebipenem pivoxil (oral carbapenem), ME1071 (metallo-β-lactamase inhibitor), TS2037 (aminoglycoside) and neticonazole (antifungal imidazole). Recently, he has promoted ME1111 program, topical antifungal drug development for onychomycosis, as a project manager.

Lloyd Czaplewski

Director, Chemical Biology Ventures
Lloyd Czaplewski

25-years of biopharmaceutical and NCE discovery and development experience from concept to clinical evaluation across multiple therapeutic areas – including anti-infective indications. He is currently CSO of Persica Pharmaceuticals Ltd which focuses on chronic low back pain and a Director of Chemical Biology Ventures Ltd which provides consulting services to biotech, academia and investors. He recently joined the Novo Repair Impact Fund Scientific Selection Board.

Mahmoud Ghannoum

Director of Center for Medical Mycology, Case Western Reserve University
Mahmoud Ghannoum

Mair Powell

Senior Medical Officer, HPRA
Mair Powell

Dr. Powell underwent post-graduate training in clinical microbiology and infectious diseases. After 11 years in hospital medicine she worked for two global pharmaceutical companies in the US and then returned to the UK to work for the MHRA from 1996-2018. In October 2018 she commenced employment with the Irish Regulatory Agency, the HPRA, where she is a senior clinical assessor. She is a member of the EMA’s Infectious Disease Working Party and was its chair for 6 years. She has been closely involved in all guideline development for anti-infective agents for 23 years. She is currently the chair of the EMA’s Vaccine Working Party and a member of the Scientific Advice Working Party.

Michael Koehler

Senior Scientist, Genentech
Michael Koehler

Michelle Buckner

Research Fellow, University of Birmingham
Michelle  Buckner

Peter Beyer

Senior Advisor , WHO
Peter Beyer

Peter Beyer, a trained lawyer, is a Senior Advisor with the World Health Organization (WHO) in Geneva where he leads a team working on antimicrobial resistance and public health, trade and intellectual property. He is responsible for the development of a global development and stewardship framework for antimicrobial resistance, including for developing new innovative funding mechanisms for research and development. Peter was instrumental in creating the Global Antibiotic R&D Partnership (GARDP) as well as the trilateral collaboration among the World Intellectual Property, the World Trade Organization and WHO. Previously, Peter Beyer was a Legal Advisor to the Swiss Federal Institute of Intellectual Property in Berne negotiating free trade agreements for the European Free Trade Association (EFTA), leading negotiations at WHO and WIPO and managing the bilateral dialogue between Switzerland and China on intellectual property. Prior to joining the Swiss civil service, Peter Beyer worked with the Ecologic Institute in Berlin on environmental law and policy. Peter Beyer was a research and teaching assistant at the University of Geneva, writing his doctoral thesis on integrated pollution control in the industrial sector. He is a graduate of the Universities of Cologne and Freiburg im Breisgau and was admitted to bar in Berlin in 2001.

Richard Bax

Senior Partner, TranScrip Partners
Richard Bax

Sergio Lociuro

Chief Scientific Officer, BioVersys AG
Sergio Lociuro

Sergio received his Laurea degree in Chemistry at the University of Rome, Italy in 1981 and, after a two-year postdoctoral fellowship at the Italian Research National Countil, he moved t o UNB, Canada, where he received his Ph.D in 1987. In the same year he started his career in the pharmaceutical industry as a medicinal chemist. In his almost 30 years experience in major pharmaceutical companies and SMEs, Sergio has held positions such as Director of Medicinal Chemistry and International Project Leader in GSK, Head of Peptide Epitope Mimetics in Polyphor Ltd and Head of Research and Scientific Communication in Arpida AG and has been part of the Board of Directors of Arpida A/S. Founder of THOT consulting Sagl, a Swiss consulting firm providing services in the Research and Development of anti-infectives and pharmaceutical drugs in general, he has lately held the position of CSO in C10 Pharma and Adenium Biotech, two Scandinavian biotech companies. His background spans from early drug discovery to late preclinical development. He has conducted Phase I clinical studies, participated in late clinical studies and in discussions with both the US FDA and EMA.

 

Stephen Barat

Head of Pre-Clinical and Early Clinical Development, SCYNEXIS Inc
Stephen Barat

Stephen A. Barat, PhD is Vice-President of Research and Early Clinical Development at Scynexis, a NJ-based biotechnology company focused on the development of novel treatments for serious and life-threatening infections. Prior to joining Scynexis, Dr. Barat held a series of positions of increasing responsibility with Allergan, Forest Laboratories and Schering-Plough. He has more than 20 years of experience in global drug development and registration, and is an internationally-recognized speaker on the subject of drug development and CMC-related safety assessment issues. Dr. Barat is a member of the PQRI PODP working group for leachables and extractables and the USP Expert Panel for Biocompatibility of Packaging Materials.

Timothy Jinks

Senior Business Analyst, Wellcome Trust
Timothy Jinks

William Hope

Professor of Therapeutics and Infectious Diseases, University Of Liverpool
William  Hope

William Hope (BMBS, FRACP, FRCPA, PhD), is Professor of Therapeutics and Infectious Diseases at the University of Liverpool in the UK. Professor Hope is a Fellow of the Royal Australasian College of Physicians and a Fellow of the Royal College of Pathologists of Australasia. Professor Hope qualified in Medicine in 1991, before undertaking specialist training in infectious diseases and clinical microbiology. He completed his PhD in antimicrobial pharmacology in 2006, while undertaking fellowships at the University of Manchester, UK, and the National Institutes of Health, Bethesda, USA. He was an NIHR Clinician Scientist and this award focused on individualised antimicrobial therapy. Professor Hope leads the newly formed Centre for Antimicrobial Pharmacodynamics, which provides the pharmacodynamic packages for new antibiotics. Areas of special interest and research are antimicrobial pharmacokinetics and pharmacodynamics, antimicrobial drug development and individualisation of antimicrobial therapy. He is a Fellow of the American Academy of Microbiology and European Society of Clinical Microbiology and Infectious Diseases.

Conference agenda

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8:30

Registration & Coffee

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9:00

Chairman's Opening Remarks

Richard Bax

Richard Bax, Senior Partner, TranScrip Partners

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9:50

The drugs don’t work: WHO’s role in advancing new antibiotics

Peter Beyer, Senior Advisor , WHO

  • Assessing the clinical and pre-clinical antibiotic development pipeline
  • Developing target product profiles for priority pathogens
  • The Global Antibiotic R&D Partnership (GARDP)
  • How to mobilize private investors for antibiotic drug development?
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10:30

Strategies to combat ß-lactamases

Christopher Schofield, Head of Organic Chemistry, Oxford University

• The β-lactams remain the most important antibiotics
• The most important mechanism of resistance to them involves serine- and metallo-β-lactamase mediated hydrolysis
• Successes and challenges in inhibiting β-lactamases will be described, highlighting the need for investment in technically demanding chemistry


 

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11:10

Morning Coffee

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12:00

A unique combination antibiotic therapy at Helperby

Anthony Coates, Chief Scientific Officer, St George's, University of London

• The combination of azidothymidine (AZT) and low-dose colistin shows synergistic antibiotic activity against carbapenem and colistin-resistant Enterobacteriaceae (CRE) infections.
• This was shown to be active against all three of the WHO Critical Priority Carbapenem resistant bacterial pathogens
• Combining antimicrobial resistance breakers such as azidothymidine with existing antibiotics has the potential to reach the market with a new class of effective antibiotic therapy in 3 to 5 years
 

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12:40

Networking Lunch

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13:40

The development of precision antibiotics: agents designed to meet the demands of stewardship

David Roblin, President of R&D, Chief Operating Officer and Chief Medical Officer, Summit Theraputics

Summit’s development strategy exemplifies good antibiotic stewardship and I will focus on two programmes from our antibiotic pipeline:

• Ridinilazole is a narrow spectrum, new mechanism of action antibiotic for the treatment of C. difficile infection and the reduction of disease recurrence.  Ridinilazole’s narrow spectrum of activity is important: it both treats the infection whilst preserving the microbiome from further perturbation and thus reducing recurrences. Summit’s Phase 3 development programme is designed to show ridinilazole has superiority over vancomycin and support its use as a new first line therapy.

• SMT-571 a novel first-in-class oral antibiotic with activity effective against the Gram-negative bacterial pathogen, Neisseria gonorrhoeae, the causative agent of the sexually transmitted infection gonorrhoea.  SMT-571 has the potential to satisfy the Target Product Profile (TPP), recommended by the World Health Organization (WHO) and Drugs for Neglected Disease initiative (DNDi) for an oral agent to treat multi-drug resistant gonorrhoea.
 

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14:20

Next generation antimicrobial therapies for lethal drug resistant bacterial infections

Chandrabali Ghose, CEO, Bioharmony Therapeutics

• Insight into the development of a pipeline of lysins for infections caused by multidrug-resistant Gram-Negative bacteria
• Demonstration of effectiveness in Gram-Negative bacteria such as Acinetobacter baumannii, Klebsiella pneumoniae, E.coli and Pseudomonas aeruginosa.
• Extreme importance due to high unmet medical need and the declining number of effective antibiotics
 

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15:00

ME1111: a Novel Antifungal Agent for Topical Treatment of Onychomycosis

Kazunori Maebashi, Senior Project Manager, Meiji Seika Pharma Co. Ltd.

•  Novel class of antifungal agent under clinical development as a topical onychomycosis treatment
•  Novel selective inhibitor of succinate dehydrogenase of dermatophyte species
•  Potent in vitro activity for dermatophyte species and in vivo efficacy in the topical treatment of experimental dermatophytosis
•  Analyzing in vitro human onychopharmacokinetic and pharmacodynamic
 

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15:40

Afternoon Tea

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16:10

Activity of Ibrexafungerp in murine models of pneumocystis pneumonia

Stephen Barat, Head of Pre-Clinical and Early Clinical Development, SCYNEXIS Inc

• Background on pneumocystis pneumonia.
• Introduction to Ibrexafungerp, the first example of the fungerps, a new class of anti-fungal agents.
• Evaluations in prophylaxis and treatment murine models of pneumocystis pneumonia.
• Potential clinical applications.
 

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16:50

Developing new therapies for fungal infection

David Cook, Chief Scientific Officer, Blueberry Therapeutics Ltd

• Fungal disease is a major public health issue that gets very little attention. Dermal fungal infections are amongst the most common but often considered “trivial”. In contrast, serious fungal infections, particularly in immune-compromised patients, have extremely high mortality rates and limited treatment options.
• Exploring efforts in the development of new treatments for common fungal infections
• Needs and challenges in developing new anti-fungals
 

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17:30

Chairman's Closing Remarks and Close of Day One

Richard Bax

Richard Bax, Senior Partner, TranScrip Partners

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8:30

Registration & Coffee

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9:00

Chairman's Opening Remarks

Lloyd Czaplewski, Director, Chemical Biology Ventures

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9:10

Regulatory considerations for the registration of new antibacterial agents

Mair Powell, Senior Medical Officer, HPRA

• Revised guidance on antibacterial drug clinical development in the EU
• Programmes for candidate antibacterial agents with potential to address an unmet need
• Considerations for beta-lactams paired with beta-lactamase inhibitors
• Other types of programmes
• Importance of understanding the pharmacokinetic-pharmacodynamic relationship

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9:50

Anti-infective research: funding, filing and finance

John  Rex

John Rex, Chief Medical Officer , F2G Ltd

• Update on funding initiatives
• Recent changes in the regulatory landscape
• Payer models: evolving global discussions
 

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10:30

Wellcome Trust: funding opportunities for anti-infective research

Timothy Jinks

Timothy Jinks, Senior Business Analyst, Wellcome Trust

• Introducing Wellcome Trust Innovations - What is our mission?
• How we are seeking innovative therapeutics and diagnostics to transform the treatment of infectious diseases
• Examples of success
• The selection process and a view of the investment selection criteria
 

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11:10

Morning Coffee

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12:20

Novel immunotherapeutics to target Gram-negative bacterial infections

Chris Pickford, Head of Drug Discovery, Centauri Therapeutics

• A summary of novel approaches to target Gram-negative bacterial infections
• Emerging immunotherapeutics
• The opportunities and challenges involved in pre-clinical development of novel immunotherapies
• Specific targeting of Gram-negative bacteria with Centauri Therapeutics AlphamersTM 
 

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13:00

Networking Lunch

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14:00

The role of plasmids in the evolution of antimicrobial resistance

Michelle  Buckner

Michelle Buckner, Research Fellow, University of Birmingham

• How have plasmids impacted the spread of antimicrobial resistance?
• What impact do plasmids have on the host bacteria?
• What novel strategies to reduce the burden of resistance plasmids are currently being explored?
 

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14:40

Novel methods for treating infections – Inducing antimicrobial peptides

Eirikur Steingrimsson, Co-founder, Akthelia Pharmaceuticals

• Akthelia has identified several small molecules that induce the production of AMPs in cells, thus leading to elimination of bacteria. 
• Several peptides are induced thereby reducing the risk of the bacteria acquiring resistance against a single peptide. 
• Thus, Akthelia’s solution treats infections by inducing the body’s own antibiotic arsenal. This mechanism has been shown to be active against most microbial pathogens, including resistant microorganisms.
• Akthelia´s actives facilitate anti-infective stewardship as they reduce the usage of classical antibiotics with minimal risk of the development of resistance.
• Importantly, they should leave the microbiota intact.
 

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15:20

Immunotherapeutics to treat life-threatening fungal infections

Fiona Rudkin, Principal Investigator/CEO, MycoBiologics at University of Aberdeen

  • New therapies are urgently required to treat life-threatening fungal infections
  • Development of novel single B cell-derived human monoclonal antibody therapeutics from patients
  • Demonstration of in vitro and in vivo effectiveness against susceptible and drug-resistant Candida species
  • Immunotherapeutics as an approach for treating life-threatening fungal infections

     

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    16:00

    Afternoon Tea

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    16:30

    Pharmacodynamics to accelerate antimicrobial drug development for AMR

    William Hope , Professor of Therapeutics and Infectious Diseases, University Of Liverpool

    • Identification of the drug's antimicrobial pharmacodynamic effects (eg, rate and extent of bactericidal action and post-antibiotic effect)
    • It provides a more rational basis for determination of optimal dosing regimens in terms of the dose and the dosing interval
    • Why it is preferred compared to minimal inhibitory concentrations (MICs) and minimal bactericidal concentrations (MBCs) determined in vitro
     

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    17:10

    Optimized arylomycins represent a new class of Gram-negative antibiotics

    Michael Koehler

    Michael Koehler, Senior Scientist, Genentech

    • Chemical optimization of the arylomycins-a class of natural products with weak activity and limited spectrum-to obtain  G0775, a molecule with potent, broad-spectrum activity against Gram-negative bacteria
    • G0775 inhibits the essential bacterial type I signal peptidase, a new antibiotic target, through an unprecedented molecular mechanism
    • It circumvents existing antibiotic resistance mechanisms and retains activity against contemporary multidrug-resistant Gram-negative clinical isolates in vitro and in several in vivo infection models
    • Optimized arylomycin analogues such as G0775 could translate into new therapies to address the growing threat of multidrug-resistant Gram-negative infections

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    17:50

    Chairman's Closing Remarks and Close of Day Two

    Lloyd Czaplewski, Director, Chemical Biology Ventures


    Chief Scientific Officer
    St George's, University of London
    Practitioner
    Fairy Gut Mother
    CEO
    Bioharmony Therapeutics
    Head of Drug Discovery
    Centauri Therapeutics
    Head of Organic Chemistry
    Oxford University
    Chief Scientific Officer
    Blueberry Therapeutics Ltd
    President of R&D, Chief Operating Officer and Chief Medical Officer
    Summit Theraputics
    Co-founder
    Akthelia Pharmaceuticals
    Principal Investigator/CEO
    MycoBiologics at University of Aberdeen
    CEO
    Phico Therapeutics
    European Partnerships Director
    GSK
    Chief Medical Officer
    F2G Ltd
    Senior Project Manager
    Meiji Seika Pharma Co. Ltd.
    Director
    Chemical Biology Ventures
    Director of Center for Medical Mycology
    Case Western Reserve University
    Senior Medical Officer
    HPRA
    Senior Scientist
    Genentech
    Research Fellow
    University of Birmingham
    Senior Advisor
    WHO
    Senior Partner
    TranScrip Partners
    Chief Scientific Officer
    BioVersys AG
    Head of Pre-Clinical and Early Clinical Development
    SCYNEXIS Inc
    Senior Business Analyst
    Wellcome Trust
    Professor of Therapeutics and Infectious Diseases
    University Of Liverpool

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    Workshops

    Understanding the complexity of the microbiome and how to navigate it
    Workshop

    Understanding the complexity of the microbiome and how to navigate it

    Holiday Inn Kensington Forum
    20 March 2019
    London, United Kingdom

    Speaker Interview with STEPHEN BARAT - SCYNEXIS

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    Speaker Interview with Co-Chair LLOYD CZAPLEWSKI

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    CO-CHAIRS LETTER OF INVITATION

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    [PAST PRESENTATIONS] - BARDA

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    [PAST PRESENTATIONS] - MSD

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    WORKSHOP B PROGRAMME

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    WORKSHOP A PROGRAMME

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    List of Speakers

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    2019 AGENDA

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    2019 Brochure

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    Past attendees 2017-2018

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    http://www.swissbiotech.org/

    The Swiss Biotech Association (SBA) is the national industry association for biotechnology, including pharmaceuticals, diagnostics, agriculture, food, cosmetics, environmental biotechnology, and specialty chemicals. Members are companies active in modern biotechnology, such as R&D, Production, Marketing and Sales, Finance, Services and Consulting. SBA provides a networking platform for Life Science clusters, academic and federal institutions the like. Founded in March 1998, the Association grows steadily.


    Infectious Diseases Hub

    Supporters
    http://www.id-hub.com

    Infectious Diseases Hub is a free-to-access website open to all researchers, students and anyone else who might have an interest in the many aspects of microbiology and virology. We offer easy access to breaking news, interviews, opinion pieces, peer-reviewed articles and multimedia features, with a strong focus on the rising issue of antimicrobial resistance. Microbiology is such a diverse and exciting area, and with the emergence of new technologies giving us the ability to study complex communities and rapidly sequence whole genomes, there has been something of a ‘revolution’. Keeping on top of such technological advances and the latest emerging diseases is at the heart of Infectious Diseases Hub, and you can take a look at up-to-date essential research and information on the site now.


    Biomedicines Journal

    Supporters
    http://www.mdpi.com/journal/biomedicines

    Biomedicines (ISSN 2227-9059) is an open access journal devoted to research of naturally driven biomedicines, pharmaceuticals, and biopharmaceutical products. The aim of Biomedicines is publishing high quality papers that address the challenges in bringing biological agents or novel targeted strategies through identification, developmentand ultimately to clinical use. It is published quarterly online by MDPI with rapid publication. Biomedicines is covered by ESCI (Web of Science) and PubMed.


    Mednous

    Supporters
    http://www.MedNous.com

    MedNous is a print publication and website about medical innovation in Europe. It carries exclusive interviews with companies that are at the forefront of medical technology, as well as contributor articles from prominent practitioners. Our mission is to identify significant advances in medicine and to explain how this innovation is being commercialised. In doing so, we talk to venture capitalists about what products and platforms they are supporting. We report on how regulators cope with the accelerating pace of innovation. And we regularly cover the latest developments in the discovery and development of new medical concepts in the area of antibodies, vaccines, small molecules, regenerative medicine and nanomedicines. MedNous combines the English word for medicine with the Greek word for intellect. And those with nous are readers of our publication. Visit our website: www.mednous.com


    IPI

    Supporters
    http://www.ipimediaworld.com

    IPI – International Pharmaceutical Industry Established by professionals with over 30 years experience in the Pharmaceutical and Life sciences publishing sectors. We have identified the needs of these dynamic industries, and have listened carefully to our readers and advertisers. With strong collaboration between Pharmaceutical and Life sciences Industry Associations we have created a global distribution network. We give you a promise to become a reliable extension of your marketing and communication arm. If necessary we will integrate our expertise with your needs. Incorporating new and innovative communication methods we will help to highlight your expertise.


    Technology Networks

    Supporters
    http://go.technologynetworks.com/subscribe-to-newsletters

    Founded in 2000, Technology Networks is established as the leading news provider for life science and drug discovery professionals. In addition, we provide unique content including webcasts, videos, application notes and posters from recent conferences. Our portfolio now includes around 30 focussed scientific communities, all of which are accessible free of charge within TechnologyNetworks.com


    Labsave

    Supporters
    http://www.labsave.com

    Labsave is the leading savings website for Laboratory Equipment and Lab Supplies. We work closely with the top suppliers in the world to bring you the best products at the most competitive prices. We are constantly striving to secure the biggest and most exclusive offers that you won’t find anywhere else! http://www.labsave.com/


    GBI

    Supporters
    http://www.gbihealth.com/

    GBI is an information, applications, and services company focused on the healthcare industry. Leveraging data from across the healthcare value chain, GBI creates web and mobile applications that enable individuals and organizations to make better decisions and communicate more effectively.


    Pharmalicensing

    Supporters
    http://www.pharmalicensing.com

    Pharmalicensing (www.pharmalicensing.com) is the premier biopharmaceutical Open Innovation resource designed for professionals involved with partnering, licensing and business development worldwide. Actively supporting all forms of partnering and in- and out-licensing activities, Pharmalicensing utilizes the unique online Showcase Profiling & Discover services, as well as its renowned Partnering Search service leveraging its global network of industry experts, to enable companies to identify and engage with appropriate partners around the world. Pharmalicensing is actively utilized by many tens of thousands of industry professionals each month. Pharmalicensing is a division of Cognis Group, Inc.


    Labcompare

    Supporters
    http://www.labcompare.com

    Labcompare is a product of American Laboratory, and is already included in the AL logo on your website. I have attached the standalone Labcompare logo and info is below, but if you do add this one separately, could you exchange the American Lab logo with the one attached? For laboratory managers and researcher scientists across analytical chemistry and applied sciences who need to find product solutions, advice, and access scientific tools. Labcompare provides an industry-leading, comprehensive, online resource of product information to support the laboratory’s needs. Labcompare supports every step of the buying journey by focusing on core and new product technology, supplies, tips, and buyer’s guides.


    Labiotech.eu

    Supporters
    https://goo.gl/DRE2Gp

    Labiotech.eu is the leading digital media covering the European Biotech industry. Over 100,000 monthly visitors use it to keep an eye on the business and innovations in biotechnology. Hope you'll enjoy reading our stories!


    Select Science

    Supporters
    http://www.selectscience.net/

    SelectScience is an independent, online information resource for the worldwide scientific community, and the home of trusted information for laboratory scientists. Discover impartial, expert opinion and trusted reviews about latest laboratory equipment and techniques; plus videos, application notes and science news from around the world. Become a member for free today.


    Biosave

    Supporters
    http://www.Biosave.com

    Biosave.com brings together the best Life Science promotions, product releases, featured products, publications, videos and events from 100’s of leading Life Science suppliers. Updated 24 hours a day, Biosave is constantly uploading special promotions and exciting product news that you won’t find anywhere else. Our goal is to provide our users with the most exclusive product information to help reach that all important purchasing decision.


    PharmaVOICE

    Supporters
    http://www.pharmavoice.com

    PharmaVOICE magazine, and its supporting VIEW publications, provide commentary about the challenges and trends impacting the life-sciences industry, covering a range of issues from molecule through market. PharmaVOICE's more than 41,000 U.S.-based subscribers are also kept abreast of the latest trends through additional media resources, including WebSeminars, Podcasts, Videocasts, and White Papers.


    SciDoc Publishers

    Supporters
    http://www.scidoc.org

    SciDoc Publishers is a major source provider of e-journals in the field of Science, Technology and Medicine (STM). The nature of journals - Open Access and Peer-reviewed. We are aimed with a sole motive in making a mark in the field of Open Access, by propagating the knowledge to the scientific community. Our prime concern involves, the knowledge to reach millions of readers and give them access to scientific publications - online.


    Drug Discovery Today

    Supporters
    http://www.drugdiscoverytoday.com/

    Drug Discovery Today covers the whole of the preclinical drug discovery process. The reviews are cutting edge, written by experts in their respective fields and cover all aspects of drug discovery from genomic and proteomic approaches, computational drug design, medicinal chemistry and the translation of these sciences to therapies.


    Farmavita

    Supporters
    https://farmavitar.com

    FarmavitaR+ is the professional network of experts and service providers. Network is gathering local consultants from 90 countries in Europe, Asia, North America, Latin America, Australia and Africa. Management of international, multi-centre projects is our core competence. FarmavitaR+ is providing solutions related to pharmaceutical, medical device, food supplement and cosmetic products. Scope of services is related to solutions for product development, quality assurance, clinical trials, product registration, portfolio analysis, lifecycle management, vigilance/risk management, pricing/reimbursing, market access and promotional compliance. FarmavitaR+ is brand name of Farmavita Regulanet Ltd. Visit https://farmavitar.com for more information. Outsource anything you can think of!


    Biocompare

    Supporters
    http://www.biocompare.com

    Biocompare.com is the leading resource for up-to-date product information, product reviews, and new technologies for life scientists. Biocompare combines an in-depth knowledge of life science products and new technologies with the power of the Internet to offer scientists the most dynamic, relevant, and innovative media-based marketplace for life science information.


    Bentham Science

    Supporters
    http://www.benthamscience.com/

    Bentham Science Publishers is a major STM journal publisher of 130 plus print and online journal. Out of these, 40 journals have already registered good IMPACT FACTORS as per Journal Citation Reports® 2017. These titles have extensive readership mostly in Europe and North America. For a detailed profile please visit our website at http://www.benthamscience.com. Besides, Bentham Science publishes eBooks in all areas of Science, Technology and Medicine. Our eBooks provide professionals, academicians, corporate researchers, graduates and undergraduates worldwide with the most current information in their subject areas of interest. Our eBooks are also available in the ePub and Kindle formats besides the PDF edition here http://ebooks.benthamscience.com/. Bentham is offering attendees of this conference discounts on its publication. For more information click here


    Drug Development Technology

    Supporters
    http://www.drugdevelopment-technology.com

    Drugdevelopment-technology.com covers every aspect of the drug development and research process, from conception to pre-FDA approval. Our global network of journalists updates the site with the latest and most significant industry developments. This coverage allows us to provide everyone - from senior management through to research and QA staff – with in-depth reviews of the latest projects, advance notice of new product releases and analysis of the latest procedural and legislative developments.


    American Pharmaceutical Review

    Supporters
    http://www.americanpharmaceuticalreview.com

    Start receiving your free copy today. American Pharmaceutical Review is a review of the drug pipeline from the late discovery phase through manufacturing. American Pharmaceutical Review prides itself on having the most relevant, unbiased and informative editorial in the industry. You will find that all of our editorial is highly technical and written by government agencies, consultants, academics, and large pharmaceuticals companies. American Pharmaceutical Review covers several key topics that are important to drug production:Separations and purification, Drug Delivery, Biopharmaceutical Processing, Biopharmaceutical Development, Formulation development, Manufacturing, Microbiology, Instrumentation, Spectroscopy

    Holiday Inn Kensington Forum

    97 Cromwell Road
    London SW7 4DN
    United Kingdom

    Holiday Inn Kensington Forum

    Holiday Inn Kensington Forum is perfectly situated in one of London’s most luxurious and beautiful areas within South Kensington. 

    The hotel is just 2 minutes walk from Gloucester Road tube station for convenient travel to Hyde Park, London Eye, Tower Bridge plus more of London’s top attractions. There are also easy and direct links to some major transport hubs including Victoria, Kings Cross St Pancras, Paddington and Heathrow. 

    This distinctive hotel in south London has so much to offer to make all guests really feel at home. The latest Holiday Inn relaunch is not just about the new look and feel for the hotel but to offer guests more benefits during their stay including a pillow menu for extra comfort during their sleep and a curved shower rail for more spacious feel. 

    In addition to our 906 rooms, all business guests can take advantage of our meeting and conference facilities including High Speed Internet Access and unlimited Starbucks coffee at The Academy. Our hotel’s professional event planners are on board to help take the hard work and stress away from planning your next event. 

    So whether you in London on business or pleasure, make the Holiday Inn London Kensington Forum your first choice of hotel and book your accommodation for our lowest internet rate guarantee. 

    HOTEL BOOKING FORM

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    WHAT IS CPD?

    CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

    ‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

    CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

    Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

    CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.

    CPD AND PROFESSIONAL INSTITUTES

    There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

    For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

    CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.

    TYPICAL CPD SCHEMES AND RECORDING OF CPD (CPD points and hours)

    Professional bodies and Institutes CPD schemes are either structured as ‘Input’ or ‘Output’ based.

    ‘Input’ based schemes list a precise number of CPD hours that individuals must achieve within a given time period. These schemes can also use different ‘currencies’ such as points, merits, units or credits, where an individual must accumulate the number required. These currencies are usually based on time i.e. 1 CPD point = 1 hour of learning.

    ‘Output’ based schemes are learner centred. They require individuals to set learning goals that align to professional competencies, or personal development objectives. These schemes also list different ways to achieve the learning goals e.g. training courses, seminars or e:learning, which enables an individual to complete their CPD through their preferred mode of learning.

    The majority of Input and Output based schemes actively encourage individuals to seek appropriate CPD activities independently.

    As a formal provider of CPD certified activities, SAE Media Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.

    GLOBAL CPD

    Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

    CPD Certificates

    We can provide a certificate for all our accredited events. To request a CPD certificate for a conference , workshop, master classes you have attended please email events@saemediagroup.com

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    Contact SAE Media Group

    UK Office
    Opening Hours: 9.00 - 17.30 (local time)
    SAE Media Group , Ground Floor, India House, 45 Curlew Street, London, SE1 2ND, United Kingdom
    Tel: +44 (0) 20 7827 6000 Fax: +44 (0) 20 7827 6001
    Website: http://www.smgconferences.com Email: events@saemediagroup.com
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